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PRIMARY LICHEN AMYLOIDOSIS: Report of Necropsy

PRIMARY LICHEN AMYLOIDOSIS: Report of Necropsy Abstract DEPOSITS of amyloid in the skin associated with widespread systemic deposits have become more generally recognized recently. Primary amyloidosis of the skin must be exceedingly uncommon, however, the first report in the American literature appearing in 1931.1 This was based on European, not American, cases. For the condition to be considered primary, there should be no evidence of deposits of amyloid in the viscera. This can be ascertained after complete postmortem examination; hence any such diagnosis during life cannot be more than presumptive. The following case fulfils these requirements. Previous reports of this case have appeared, once in 1939 before the Philadelphia Dermatological Society2 and prior to that by Herman and Lyon in 1921.3 The present report summarizes the findings which appeared in these reports and the subsequent course. REPORT OF A CASE J. R., a Spaniard residing in Cuba from 1889 to 1906, suffered a severe References 1. Winer, L. H.: Local Amyloidosis of the Skin , Arch. Dermat. & Syph. 23:866 ( (May) ) 1931. 2. Greenbaum, S. S.: Lichen Amyloidosus and Prurigo Associated at One Time with Pseudopolycythemia and Visceral Suppuration , Arch. Dermat. & Syph. 39:380 ( (Feb.) ) 1939. 3. Herman, L., and Lyon, B. B. V.: Pseudopolycythemia: Extraordinary Blood Changes in a Patient with Renal Calculus , Ann. Surg. 73:223 ( (Feb.) ) 1921. 4. Koletsky, S., and Stecher, R. M.: Primary Systemic Amyloidosis: Involvement of Cardiac Valves, Joints and Bones, with Pathologic Fracture of the Femur , Arch. Path. 27:267 ( (Feb.) ) 1939. 5. Lindsay, S., and Knorp, W. F.: Primary Systemic Amyloidosis , Arch. Path. 39:315 ( (May) ) 1945. 6. Hass, G., and Schulz, R. Z.: Amyloid: I. Methods of Isolating Amyloid from Other Tissue Elements , Arch. Path. 30:240 ( (July) ) 1940. 7. Hass, G.: Studies of Amyloid: II. The Isolation of a Polysaccharide from Amyloid-Bearing Tissues , Arch. Path. 34:92 ( (July) ) 1942. 8. Hass, G. M.; Huntington, R., and Krumdieck, N.: Amyloid: III. The Properties of Amyloid Deposits Occurring in Several Species Under Diverse Conditions , Arch. Path. 35:226 ( (Feb.) ) 1943. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

PRIMARY LICHEN AMYLOIDOSIS: Report of Necropsy

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Publisher
American Medical Association
Copyright
Copyright © 1947 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1947.01520020106008
Publisher site
See Article on Publisher Site

Abstract

Abstract DEPOSITS of amyloid in the skin associated with widespread systemic deposits have become more generally recognized recently. Primary amyloidosis of the skin must be exceedingly uncommon, however, the first report in the American literature appearing in 1931.1 This was based on European, not American, cases. For the condition to be considered primary, there should be no evidence of deposits of amyloid in the viscera. This can be ascertained after complete postmortem examination; hence any such diagnosis during life cannot be more than presumptive. The following case fulfils these requirements. Previous reports of this case have appeared, once in 1939 before the Philadelphia Dermatological Society2 and prior to that by Herman and Lyon in 1921.3 The present report summarizes the findings which appeared in these reports and the subsequent course. REPORT OF A CASE J. R., a Spaniard residing in Cuba from 1889 to 1906, suffered a severe References 1. Winer, L. H.: Local Amyloidosis of the Skin , Arch. Dermat. & Syph. 23:866 ( (May) ) 1931. 2. Greenbaum, S. S.: Lichen Amyloidosus and Prurigo Associated at One Time with Pseudopolycythemia and Visceral Suppuration , Arch. Dermat. & Syph. 39:380 ( (Feb.) ) 1939. 3. Herman, L., and Lyon, B. B. V.: Pseudopolycythemia: Extraordinary Blood Changes in a Patient with Renal Calculus , Ann. Surg. 73:223 ( (Feb.) ) 1921. 4. Koletsky, S., and Stecher, R. M.: Primary Systemic Amyloidosis: Involvement of Cardiac Valves, Joints and Bones, with Pathologic Fracture of the Femur , Arch. Path. 27:267 ( (Feb.) ) 1939. 5. Lindsay, S., and Knorp, W. F.: Primary Systemic Amyloidosis , Arch. Path. 39:315 ( (May) ) 1945. 6. Hass, G., and Schulz, R. Z.: Amyloid: I. Methods of Isolating Amyloid from Other Tissue Elements , Arch. Path. 30:240 ( (July) ) 1940. 7. Hass, G.: Studies of Amyloid: II. The Isolation of a Polysaccharide from Amyloid-Bearing Tissues , Arch. Path. 34:92 ( (July) ) 1942. 8. Hass, G. M.; Huntington, R., and Krumdieck, N.: Amyloid: III. The Properties of Amyloid Deposits Occurring in Several Species Under Diverse Conditions , Arch. Path. 35:226 ( (Feb.) ) 1943.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Feb 1, 1947

References