Abstract In 1849, Carl von Rokitansky insisted that primary carcinoma of the liver was a common affection. He also separated primary from secondary lesions of the liver. Virchow warned that before a diagnosis of primary carcinoma of the liver could be made, a careful search of the eye, breast, and gastrointestinal tract should be made. In 1879, Kelsch and Kiener reviewed the literature and found only 1 case of primary liver carcinoma which they considered authentic, to which they added 2 of their own. In 1881 Sabourin added 4 more cases. Prior to Sabourin primary carcinoma of the liver was considered commoner than secondary cancers; hence, statistics gained from many early case reports and death certificates are invalid, because there was no histologic confirmation. By 1901 Eggel found 163 cases, and in 1939 Charache's exhaustive search of the world literature produced 1,125 cases.1 A study of the primary carcinoma of References 1. Leavitt, D., et al.: Primary Carcinoma of the Liver: Case Report and Review of Literature , A.M.A. Arch. Surg. 73:114-126, 1959. 2. Gillman, J., and Payet, M.: Primary Carcinoma of the Liver (Statistical, Anatomical and Etiological Considerations) , Acta Un. Int. Cancr. 13:861-873, 1957. 3. Denoix, P. F.; Schlumberger, J. R.; Lauraut, C., and Maryoe, L.: Carcinoma in African Negroes in French Africa , Acta Un. Int. Cancr. 13:942-948, 1957. 4. Davies, J. N. P.: Cancer in Relation to Other Diseases in Africa , Acta Un. Int. Cancr. 13:893-903, 1957. 5. Payet, M.: African Cirrhosis in Relation to Primitive Cancer of the Liver , Acta Un. Int. Cancr. 13:712-716, 1957. 6. Steiner, P. E.: Cancer and Races, with Emphasis on the American and African Negroes and on the Mexicans , Acta Un. Int. Cancr. 13: 959-966, 1957. 7. Higginson, J., and Oettle, A. F.: Incidence of Cancer in the South African Bantu , Acta Un. Int. Cancr. 13:945-955, 1957. 8. Cantarow, A.: Endocrinological Aspects of Liver Disease , Acta Un. Int. Cancr. 13:740-755, 1957. 9. Higginson, J.: Malignant Neoplastic Disease in the South African Bantu , Cancer 4:1224, 1951.Crossref 10. Higginson, J.: Primary Carcinoma of the Liver in Africa , Brit. J. Cancer 10:609-622, 1956.Crossref 11. Edington, G. M.: Malignant Disease in the Gold Coast , Brit. J. Cancer 10:595, 1956.Crossref 12. McDonald, A. R.: Cirrhosis and Primary Carcinoma of the Liver , New Engl. J. Med. 225: 1179, 1956.Crossref 13. Pene, P.: Les conditions d'apparition du cancer primitif du foie , J. Med. de Dakar 8:31-33, 1958. 14. Laffont, A., et al.: Aspect gynecologique du cancer primitif du foie , J. Med. de Dakar 8:35, 1958.
Archives of Surgery – American Medical Association
Published: Nov 1, 1961