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PREVENTION OF UNINTENTIONAL ISOIMMUNIZATION OF THE RH NEGATIVE FEMALE POPULATION

PREVENTION OF UNINTENTIONAL ISOIMMUNIZATION OF THE RH NEGATIVE FEMALE POPULATION The obstetric history of mothers of erythroblastotic infants reveals that this condition, as a rule, does not occur in the first born. Frequently the first one, two or more Rh + infants are normal. From the point of view of isoimmunization, it is clear that oneor more pregnancies with Rh + offspring are required to induce a state of isoimmunization sufficiently intense to produce the hemolytic condition in the following Rh + infant.1 In other words, the first one or more pregnancies serve the same preparatoryfunction as repeated uneventful transfusions of an Rh − male patient with Rh + blood. The study to be presented indicates the importance of prevention of the deliberate isoimmunization of the Rh − female population, including even the newborn infant, by transfusions with Rh + blood.2 Evidence is produced to indicate that even the first born is frequently lost as a result of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

PREVENTION OF UNINTENTIONAL ISOIMMUNIZATION OF THE RH NEGATIVE FEMALE POPULATION

JAMA , Volume 128 (13) – Jul 28, 1945

PREVENTION OF UNINTENTIONAL ISOIMMUNIZATION OF THE RH NEGATIVE FEMALE POPULATION

Abstract


The obstetric history of mothers of erythroblastotic infants reveals that this condition, as a rule, does not occur in the first born. Frequently the first one, two or more Rh + infants are normal. From the point of view of isoimmunization, it is clear that oneor more pregnancies with Rh + offspring are required to induce a state of isoimmunization sufficiently intense to produce the hemolytic condition in the following Rh + infant.1 In other words, the first one or more pregnancies serve...
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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1945 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1945.92860300003007a
Publisher site
See Article on Publisher Site

Abstract

The obstetric history of mothers of erythroblastotic infants reveals that this condition, as a rule, does not occur in the first born. Frequently the first one, two or more Rh + infants are normal. From the point of view of isoimmunization, it is clear that oneor more pregnancies with Rh + offspring are required to induce a state of isoimmunization sufficiently intense to produce the hemolytic condition in the following Rh + infant.1 In other words, the first one or more pregnancies serve the same preparatoryfunction as repeated uneventful transfusions of an Rh − male patient with Rh + blood. The study to be presented indicates the importance of prevention of the deliberate isoimmunization of the Rh − female population, including even the newborn infant, by transfusions with Rh + blood.2 Evidence is produced to indicate that even the first born is frequently lost as a result of

Journal

JAMAAmerican Medical Association

Published: Jul 28, 1945

There are no references for this article.