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Prevention of Rubella During an Epidemic on Taiwan: HPV-77 and RA 27/3 Rubella Vaccines Administered Subcutaneously and Intranasally HPV-77 Vaccine Mixed With Mumps and/or Measles Vaccines

Prevention of Rubella During an Epidemic on Taiwan: HPV-77 and RA 27/3 Rubella Vaccines... Abstract SINCE the isolation of the rubella virus in 1962,1,2 extensive research has been directed toward the development of a safe, effective vaccine. Several live attenuated vaccine strains have been developed and tested for safety, immunogenicity, and communicability in the United States and Europe.3-7 An island-wide epidemic of rubella on Taiwan, beginning early in 1968, provided the first opportunity for the evaluation of the clinical efficacy of some of these vaccines. Unlike other large populations, rubella is not endemic on Taiwan: island-wide epidemics are known to have occurred in 1944 and 1957 to 1958 with complete absence of disease in the intervening years.8 Those born since the latter epidemic were shown to be serologically susceptible shortly before the beginning of the 1968 epidemic,9 which began in northern Taiwan and spread rapidly southward with variable but generally high attack rates. Earlier studies in northern Taiwan schoolboys with one References 1. Parkman, P.D.; Buescher, E.L.; and Artenstein, M.S.: Recovery of Rubella Virus From Army Recruits , Proc Soc Exp Biol Med 111:225-230 ( (Oct) ) 1962.Crossref 2. Weller, T.H., and Neva, F.A.: Propagation in Tissue Culture of Cytopathic Agents From Patients With Rubella-like Illnesses , Proc Soc Exp Biol Med 111:215-224 ( (Oct) ) 1962.Crossref 3. Parkman, P.D., et al: Attenuated Rubella Virus: I. Development and Laboratory Characterization , New Eng J Med 275:569-574 ( (Sept 15) ) 1966.Crossref 4. Parkman, P.D., and Meyer, H.M., Jr.: Prospects for a Rubella Virus Vaccine, Prog Med Virol, to be published. 5. Meyer, H.M., Jr., et al: Clinical Studies With Experimental Live Rubella Virus Vaccine (Strain HPV-77): Evaluation of Vaccine Induced Immunity , Amer J Dis Child 115:648-654 ( (June) ) 1968.Crossref 6. Du Pan, M.R., et al: Attentuation of Rubella Virus by Serial Passage in Primary Rabbit Kidney Cells: III. Clinical Trials in Infants , Pediat Res 2: 38-42 ( (Jan) ) 1968.Crossref 7. Plotkin, S.A., et al: A New Attenuated Rubella Virus Grown in Human Fibroblasts: Evidence for Reduced Nasopharyngeal Excretion , Amer J Epidem 86:468-477 ( (March) )1967. 8. Gale, J.L., et al: The Epidemiology of Rubella on Taiwan , Amer J Dis Child 118:143-145 ( (July) ) 1969. 9. Detels, R., et al: The Efficacy of Three HPV-77 Vaccines in the Prevention of Clinical and Subclinical Rubella Infection , Amer J Dis Child 118: 295-300 ( (Aug) ) 1969.Crossref 10. Grayston, J.T., et al: Field Trial of Live Attenuated Rubella Vaccine During an Epidemic on Taiwan: Preliminary Report of Efficacy of Three HPV-77 Strain Vaccines in Prevention of Clinical Rubella , JAMA 207:1107-1110 ( (Feb 10) ) 1969.Crossref 11. Plotkin, S.A.; Cornfield, D.; and Ingalls, T.H.: Studies of Immunization With Living Rubella Virus: Trials in Children With a Strain Cultured From an Aborted Fetus , Amer J Dis Child 110:381-389 ( (Oct) ) 1965.Crossref 12. Stewart, G.L., et al: Rubella Virus Hemagglutination-Inhibition Test , New Eng J Med 276:554-557 ( (March) ) 1967.Crossref 13. Schacher, S.A., et al: Oral Administration of Attenuated Rubella Virus Vaccine (HPV-77): A Negative Report , J Pediat 72:255-257 ( (Feb) ) 1968.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Prevention of Rubella During an Epidemic on Taiwan: HPV-77 and RA 27/3 Rubella Vaccines Administered Subcutaneously and Intranasally HPV-77 Vaccine Mixed With Mumps and/or Measles Vaccines

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1969.02100040303027
Publisher site
See Article on Publisher Site

Abstract

Abstract SINCE the isolation of the rubella virus in 1962,1,2 extensive research has been directed toward the development of a safe, effective vaccine. Several live attenuated vaccine strains have been developed and tested for safety, immunogenicity, and communicability in the United States and Europe.3-7 An island-wide epidemic of rubella on Taiwan, beginning early in 1968, provided the first opportunity for the evaluation of the clinical efficacy of some of these vaccines. Unlike other large populations, rubella is not endemic on Taiwan: island-wide epidemics are known to have occurred in 1944 and 1957 to 1958 with complete absence of disease in the intervening years.8 Those born since the latter epidemic were shown to be serologically susceptible shortly before the beginning of the 1968 epidemic,9 which began in northern Taiwan and spread rapidly southward with variable but generally high attack rates. Earlier studies in northern Taiwan schoolboys with one References 1. Parkman, P.D.; Buescher, E.L.; and Artenstein, M.S.: Recovery of Rubella Virus From Army Recruits , Proc Soc Exp Biol Med 111:225-230 ( (Oct) ) 1962.Crossref 2. Weller, T.H., and Neva, F.A.: Propagation in Tissue Culture of Cytopathic Agents From Patients With Rubella-like Illnesses , Proc Soc Exp Biol Med 111:215-224 ( (Oct) ) 1962.Crossref 3. Parkman, P.D., et al: Attenuated Rubella Virus: I. Development and Laboratory Characterization , New Eng J Med 275:569-574 ( (Sept 15) ) 1966.Crossref 4. Parkman, P.D., and Meyer, H.M., Jr.: Prospects for a Rubella Virus Vaccine, Prog Med Virol, to be published. 5. Meyer, H.M., Jr., et al: Clinical Studies With Experimental Live Rubella Virus Vaccine (Strain HPV-77): Evaluation of Vaccine Induced Immunity , Amer J Dis Child 115:648-654 ( (June) ) 1968.Crossref 6. Du Pan, M.R., et al: Attentuation of Rubella Virus by Serial Passage in Primary Rabbit Kidney Cells: III. Clinical Trials in Infants , Pediat Res 2: 38-42 ( (Jan) ) 1968.Crossref 7. Plotkin, S.A., et al: A New Attenuated Rubella Virus Grown in Human Fibroblasts: Evidence for Reduced Nasopharyngeal Excretion , Amer J Epidem 86:468-477 ( (March) )1967. 8. Gale, J.L., et al: The Epidemiology of Rubella on Taiwan , Amer J Dis Child 118:143-145 ( (July) ) 1969. 9. Detels, R., et al: The Efficacy of Three HPV-77 Vaccines in the Prevention of Clinical and Subclinical Rubella Infection , Amer J Dis Child 118: 295-300 ( (Aug) ) 1969.Crossref 10. Grayston, J.T., et al: Field Trial of Live Attenuated Rubella Vaccine During an Epidemic on Taiwan: Preliminary Report of Efficacy of Three HPV-77 Strain Vaccines in Prevention of Clinical Rubella , JAMA 207:1107-1110 ( (Feb 10) ) 1969.Crossref 11. Plotkin, S.A.; Cornfield, D.; and Ingalls, T.H.: Studies of Immunization With Living Rubella Virus: Trials in Children With a Strain Cultured From an Aborted Fetus , Amer J Dis Child 110:381-389 ( (Oct) ) 1965.Crossref 12. Stewart, G.L., et al: Rubella Virus Hemagglutination-Inhibition Test , New Eng J Med 276:554-557 ( (March) ) 1967.Crossref 13. Schacher, S.A., et al: Oral Administration of Attenuated Rubella Virus Vaccine (HPV-77): A Negative Report , J Pediat 72:255-257 ( (Feb) ) 1968.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Aug 1, 1969

References