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Prevention of Nonvertebral Fractures With Oral Vitamin D and Dose Dependency

Prevention of Nonvertebral Fractures With Oral Vitamin D and Dose Dependency REVIEW ARTICLE Prevention of Nonvertebral Fractures With Oral Vitamin D and Dose Dependency A Meta-analysis of Randomized Controlled Trials Heike A. Bischoff-Ferrari, DrPH; Walter C. Willett, DrPH; John B. Wong, MD; Andreas E. Stuck, MD; Hannes B. Staehelin, MD; E. John Orav, PhD; Anna Thoma, MD; Douglas P. Kiel, MD; Jana Henschkowski, MD Background: Antifracture efficacy with supplemental ture efficacy increased significantly with a higher dose vitamin D has been questioned by recent trials. and higher achieved blood 25-hydroxyvitamin D levels for both end points. Consistently, pooling trials with a Methods: We performed a meta-analysis on the efficacy higher received dose of more than 400 IU/d resolved of oral supplemental vitamin D in preventing nonverte- heterogeneity. For the higher dose, the pooled RR was 0.80 (95% CI, 0.72-0.89; n = 33 265 subjects from 9 trials) bral and hip fractures among older individuals (65 years). for nonvertebral fractures and 0.82 (95% CI, 0.69-0.97; We included 12 double-blind randomized controlled trials n = 31 872 subjects from 5 trials) for hip fractures. The (RCTs) for nonvertebral fractures (n = 42 279) and 8 RCTs higher dose reduced nonvertebral fractures in community- for hip fractures (n = 40 886) comparing oral http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/archinternmed.2008.600
pmid
19307517
Publisher site
See Article on Publisher Site

Abstract

REVIEW ARTICLE Prevention of Nonvertebral Fractures With Oral Vitamin D and Dose Dependency A Meta-analysis of Randomized Controlled Trials Heike A. Bischoff-Ferrari, DrPH; Walter C. Willett, DrPH; John B. Wong, MD; Andreas E. Stuck, MD; Hannes B. Staehelin, MD; E. John Orav, PhD; Anna Thoma, MD; Douglas P. Kiel, MD; Jana Henschkowski, MD Background: Antifracture efficacy with supplemental ture efficacy increased significantly with a higher dose vitamin D has been questioned by recent trials. and higher achieved blood 25-hydroxyvitamin D levels for both end points. Consistently, pooling trials with a Methods: We performed a meta-analysis on the efficacy higher received dose of more than 400 IU/d resolved of oral supplemental vitamin D in preventing nonverte- heterogeneity. For the higher dose, the pooled RR was 0.80 (95% CI, 0.72-0.89; n = 33 265 subjects from 9 trials) bral and hip fractures among older individuals (65 years). for nonvertebral fractures and 0.82 (95% CI, 0.69-0.97; We included 12 double-blind randomized controlled trials n = 31 872 subjects from 5 trials) for hip fractures. The (RCTs) for nonvertebral fractures (n = 42 279) and 8 RCTs higher dose reduced nonvertebral fractures in community- for hip fractures (n = 40 886) comparing oral

Journal

JAMA Internal MedicineAmerican Medical Association

Published: Mar 23, 2009

References