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"If we are to use long-term anticoagulant therapy in coronary heart disease, when shall we start the therapy? There is general agreement that this treatment is prophylactic and not curative. From the vast literature on this subject it seems that the overwhelming majority has settled for preventing the second or subsequent infarctions. Surprisingly few have tried to prevent the first infarction, which probably has a four week mortality of close to 40%."
JAMA – American Medical Association
Published: Feb 15, 1964
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