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Preventing Cardiotoxicity Associated With Breast Cancer Therapy

Preventing Cardiotoxicity Associated With Breast Cancer Therapy News & Analysis Clinical Trials Update Preventing Cardiotoxicity Associated sion severity than did the comparator group. With Breast Cancer Therapy Clinically meaningful improvements were An angiotensin-converting enzyme (ACE) seen in the esketamine group 24 hours af- inhibitor and β-blocker prevented cardio- ter a single dose. In the esketamine group, toxicity associated with combination 7% discontinued the study drug due to ad- chemotherapy in women with ERBB2 verse events compared with 0.9% of the (formerly HER2)–positive breast cancer, re- comparator group. Esketamine-related ad- ported a trial in the Journal of the American verse events, including nausea, dissocia- College of Cardiology. tion, vertigo, and dizziness, usually re- Thestudyincluded468womenreceiving solved by 1.5 hours. 12 months of trastuzumab chemotherapy. Participants were stratified by anthracycline Yoga for Anxiety and Depression chemotherapy use and randomized to 1 of 3 Associated With Parkinson Disease groups: placebo, lisinopril (ACE inhibitor), or Mindfulness yoga was more effective in re- carvedilol (β-blocker) treatment. lieving the psychological distress of Parkin- Cardiotoxicitywascomparableacrossthe son disease (PD) than conventional exer- Lisinopril and carvedilol prevented cardiotoxicity 3 groups for the entire study cohort. How- cise, according to a trial in JAMA Neurology. among women with breast cancer. ever, for women receiving combination an- The http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Preventing Cardiotoxicity Associated With Breast Cancer Therapy

JAMA , Volume 322 (4) – Jul 23, 2019

Preventing Cardiotoxicity Associated With Breast Cancer Therapy

Abstract

News & Analysis Clinical Trials Update Preventing Cardiotoxicity Associated sion severity than did the comparator group. With Breast Cancer Therapy Clinically meaningful improvements were An angiotensin-converting enzyme (ACE) seen in the esketamine group 24 hours af- inhibitor and β-blocker prevented cardio- ter a single dose. In the esketamine group, toxicity associated with combination 7% discontinued the study drug due to ad- chemotherapy in women with ERBB2 verse events compared...
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Publisher
American Medical Association
Copyright
Copyright 2019 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2019.9782
Publisher site
See Article on Publisher Site

Abstract

News & Analysis Clinical Trials Update Preventing Cardiotoxicity Associated sion severity than did the comparator group. With Breast Cancer Therapy Clinically meaningful improvements were An angiotensin-converting enzyme (ACE) seen in the esketamine group 24 hours af- inhibitor and β-blocker prevented cardio- ter a single dose. In the esketamine group, toxicity associated with combination 7% discontinued the study drug due to ad- chemotherapy in women with ERBB2 verse events compared with 0.9% of the (formerly HER2)–positive breast cancer, re- comparator group. Esketamine-related ad- ported a trial in the Journal of the American verse events, including nausea, dissocia- College of Cardiology. tion, vertigo, and dizziness, usually re- Thestudyincluded468womenreceiving solved by 1.5 hours. 12 months of trastuzumab chemotherapy. Participants were stratified by anthracycline Yoga for Anxiety and Depression chemotherapy use and randomized to 1 of 3 Associated With Parkinson Disease groups: placebo, lisinopril (ACE inhibitor), or Mindfulness yoga was more effective in re- carvedilol (β-blocker) treatment. lieving the psychological distress of Parkin- Cardiotoxicitywascomparableacrossthe son disease (PD) than conventional exer- Lisinopril and carvedilol prevented cardiotoxicity 3 groups for the entire study cohort. How- cise, according to a trial in JAMA Neurology. among women with breast cancer. ever, for women receiving combination an- The

Journal

JAMAAmerican Medical Association

Published: Jul 23, 2019

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