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Prevalence and Characteristics of Undiagnosed Bipolar Disorders in Patients With a Major Depressive Episode

Prevalence and Characteristics of Undiagnosed Bipolar Disorders in Patients With a Major... ORIGINAL ARTICLE Prevalence and Characteristics of Undiagnosed Bipolar Disorders in Patients With a Major Depressive Episode The BRIDGE Study Jules Angst, MD; Jean-Michel Azorin, MD; Charles L. Bowden, MD; Giulio Perugi, MD; Eduard Vieta, MD, PhD; Alex Gamma, PhD; Allan H. Young, MD, PhD; for the BRIDGE Study Group Context: Major depressive disorder, the most com- teria. Variables associated with bipolarity were assessed mon psychiatric illness, is often chronic and a major using logistic regression. cause of disability. Many patients with major depres- sive episodes who have an underlying but unrecog- Results: A total of 903 patients fulfilled DSM-IV-TR cri- nized bipolar disorder receive pharmacologic treat- teria for bipolar disorder (16.0%; 95% confidence inter- ment with ineffective regimens that do not include val, 15.1%-17.0%), whereas 2647 (47.0%; 95% confi- mood stabilizers. dence interval, 45.7%-48.3%) met the bipolarity specifier criteria. Using both definitions, significant associations (odds Objective: To determine the frequency of bipolar dis- ratio2; P.001) with bipolarity were observed for fam- order symptoms in patients seeking treatment for a ma- ily history of mania/hypomania and multiple past mood epi- jor depressive episode. sodes. The bipolarity specifier additionally identified sig- nificant associations for manic/hypomanic states during Design: Multicenter, multinational, transcultural, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Prevalence and Characteristics of Undiagnosed Bipolar Disorders in Patients With a Major Depressive Episode

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Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/archgenpsychiatry.2011.87
pmid
21810644
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL ARTICLE Prevalence and Characteristics of Undiagnosed Bipolar Disorders in Patients With a Major Depressive Episode The BRIDGE Study Jules Angst, MD; Jean-Michel Azorin, MD; Charles L. Bowden, MD; Giulio Perugi, MD; Eduard Vieta, MD, PhD; Alex Gamma, PhD; Allan H. Young, MD, PhD; for the BRIDGE Study Group Context: Major depressive disorder, the most com- teria. Variables associated with bipolarity were assessed mon psychiatric illness, is often chronic and a major using logistic regression. cause of disability. Many patients with major depres- sive episodes who have an underlying but unrecog- Results: A total of 903 patients fulfilled DSM-IV-TR cri- nized bipolar disorder receive pharmacologic treat- teria for bipolar disorder (16.0%; 95% confidence inter- ment with ineffective regimens that do not include val, 15.1%-17.0%), whereas 2647 (47.0%; 95% confi- mood stabilizers. dence interval, 45.7%-48.3%) met the bipolarity specifier criteria. Using both definitions, significant associations (odds Objective: To determine the frequency of bipolar dis- ratio2; P.001) with bipolarity were observed for fam- order symptoms in patients seeking treatment for a ma- ily history of mania/hypomania and multiple past mood epi- jor depressive episode. sodes. The bipolarity specifier additionally identified sig- nificant associations for manic/hypomanic states during Design: Multicenter, multinational, transcultural,

Journal

JAMA PsychiatryAmerican Medical Association

Published: Aug 1, 2011

References