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Pretibial Myxedema Associated With Chronic Thyroiditis

Pretibial Myxedema Associated With Chronic Thyroiditis Abstract To the Editor.— Pretibial myxedema (PM) is sometimes seen in the patients with thyroid dysfunction, most commonly Graves' disease.1 I report herein a case of pretibial myxedema that was observed in a patient with chronic lymphocytic thyroiditis. Report of a Case.— A 43-year-old woman was noted to have slowly growing skin eruptions on the lower part of the legs in June 1981. Physical examination revealed reddish plaques with an "orangepeellike" appearance and coarse hairs on her both legs, mild exophthalmos with periorbital edema, clubbed fingers, and diffuse goiter. Routine laboratory test results were within normal limits, except for high titer of antimicrosomal antibody. Longacting thyroid stimulator was absent. Several thyroid function tests revealed a pattern of hyperthyroidism.Histology of the skin lesion showed dense mucin deposition in the middle and lower dermis stained with toluidine blue solution, the mucin was digested with testicular hyaluronidase.A thyroid biopsy specimen revealed References 1. Danforth WH, Humphrey HA: Hypertrophic osteoarthropathy and pretibial myxedema associated with Graves' disease . J Clin Endocrinol Metabol 1958;18:1302-1307.Crossref 2. Hyder NA: Exophthalmos, digital clubbing and pretibial myxedema in thyroiditis . J Clin Endocrinol Metabol 1963;23:215-217.Crossref 3. Lynch PJ, Maize JC, Sisson JC: Pretibial myxedema and nonthyrotoxic thyroid disease . Arch Dermatol 1973;107:107-111.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Pretibial Myxedema Associated With Chronic Thyroiditis

Archives of Dermatology , Volume 121 (4) – Apr 1, 1985

Pretibial Myxedema Associated With Chronic Thyroiditis

Abstract

Abstract To the Editor.— Pretibial myxedema (PM) is sometimes seen in the patients with thyroid dysfunction, most commonly Graves' disease.1 I report herein a case of pretibial myxedema that was observed in a patient with chronic lymphocytic thyroiditis. Report of a Case.— A 43-year-old woman was noted to have slowly growing skin eruptions on the lower part of the legs in June 1981. Physical examination revealed reddish plaques with an "orangepeellike" appearance...
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Publisher
American Medical Association
Copyright
Copyright © 1985 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1985.01660040025007
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Pretibial myxedema (PM) is sometimes seen in the patients with thyroid dysfunction, most commonly Graves' disease.1 I report herein a case of pretibial myxedema that was observed in a patient with chronic lymphocytic thyroiditis. Report of a Case.— A 43-year-old woman was noted to have slowly growing skin eruptions on the lower part of the legs in June 1981. Physical examination revealed reddish plaques with an "orangepeellike" appearance and coarse hairs on her both legs, mild exophthalmos with periorbital edema, clubbed fingers, and diffuse goiter. Routine laboratory test results were within normal limits, except for high titer of antimicrosomal antibody. Longacting thyroid stimulator was absent. Several thyroid function tests revealed a pattern of hyperthyroidism.Histology of the skin lesion showed dense mucin deposition in the middle and lower dermis stained with toluidine blue solution, the mucin was digested with testicular hyaluronidase.A thyroid biopsy specimen revealed References 1. Danforth WH, Humphrey HA: Hypertrophic osteoarthropathy and pretibial myxedema associated with Graves' disease . J Clin Endocrinol Metabol 1958;18:1302-1307.Crossref 2. Hyder NA: Exophthalmos, digital clubbing and pretibial myxedema in thyroiditis . J Clin Endocrinol Metabol 1963;23:215-217.Crossref 3. Lynch PJ, Maize JC, Sisson JC: Pretibial myxedema and nonthyrotoxic thyroid disease . Arch Dermatol 1973;107:107-111.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Apr 1, 1985

References