Abstract The problem of the possible significance of renin in the production of hypertension is fundamentally important in determining possible approaches to the therapeusis of this disorder. The available evidence on this point is, however, conflicting. Thus, Harrison, Blalock, Mason and Williams1 and Prinzmetal, Friedman and Abramson2 observed that extracts of ischemic dog kidneys cause a greater rise in blood pressure than do those of normal kidneys. On the other hand, Pickering and Prinzmetal3 failed to observe an augmented pressor effect in extracts of ischemic rabbit kidneys, while Beckwith and Chanutin4 found that the pressor activity of the kidney remnants of rats with hypertension due to subtotal nephrectomy was less than that of normal kidneys from rats with normal blood pressure. Several possible explanations for the divergent results obtained by previous workers suggest themselves: (1) differences in methods of preparation; (2) species differences of the animals (dog, References 1. Harrison, T. R.; Blalock, A.; Mason, M., and Williams, J. R., Jr.: Relation of Kidneys to Blood Pressure: Effects of Extracts of Kidneys of Normal Dogs and of Dogs with Renal Hypertension on Blood Pressure of Rats , Arch. Int. Med. 60:1058 ( (Dec.) ) 1937.Crossref 2. Prinzmetal, M.; Friedman, B., and Abramson, D. I.: Nature of Arterial Hypertension with Special Reference to the Role of the Kidney , Ann. Int. Med. 12:1604, 1939.Crossref 3. Pickering, G. W., and Prinzmetal, M.: Some Observations on Renin, Pressor Substance Contained in Normal Kidney, Together with Method for Its Biological Assay , Clin. Sc. 3:211, 1938. 4. Beckwith, J. R., and Chanutin, A.: The Pressor Effect of Kidney Extracts of Intact and Partially Nephrectomized Rats , Am. J. Physiol. 128:562, 1940. 5. Grossman, E. B., and Williams, J. R., Jr.: Relation of Age to the Renal Pressor Substance , Arch. Int. Med. 62:799 ( (Nov.) ) 1938.Crossref 6. Kohlstaedt, K. G.; Helmer, O. M., and Page, I. H.: Activation of Renin by Blood Colloids , Proc. Soc. Exper. Biol. & Med. 38:214, 1938. 7. Page, I. H.: On the Nature of the Pressor Action of Renin , J. Exper. Med. 70:521, 1939 8. Braun-Menendez, E.; Fasciolo, J. C.; Leloir, L. F., and Muñoz, J. M.: Rev. Soc. argent. de biol. 15:420, 1939. 9. Braun-Menendez, E., and Fasciolo, J. C.: Rev. Soc. argent. de biol. 15:161, 1939 10. Harrison, T. R.; Mason, M. F.; Resnik, H., and Rainey, J.: Changes in Blood Pressure in Relation to Experimental Renal Insufficiency , Tr. A. Am. Physicians 51: 280, 1936. 11. Blalock, A., and Levy, S. E.: Studies on the Etiology of Renal Hypertension , Ann. Surg. 106:826, 1937. 12. Prinzmetal, M., and Wilson, C.: The Nature of the Peripheral Resistance in Arterial Hypertension with Special Reference to the Vasomotor System , J. Clin. Investigation 15:63, 1936. 13. Landis, E. M.; Montgomery, H., and Sparkman, D.: Effects of Pressor Drugs and of Saline Kidney Extracts on the Blood Pressure and Skin Temperature , J. Clin. Investigation 17:189, 1938. 14. Goldblatt, H.: Studies on Experimental Hypertension: Pathogenesis of Experimental Hypertension Due to Renal Ischemia , Ann. Int. Med. 11:69, 1937. 15. Blalock, A., and Levy, S. E.: Studies on the Etiology of Renal Hypertension , Ann. Surg. 106:826, 1937. 16. Page, I. H.: Effect of Bilateral Adrenalectomy on Arterial Blood Pressure of Dogs with Experimental Hypertension , Am. J. Physiol. 122: 352, 1938. 17. Collins, D. A., and Wood, E. H.: Experimental Renal Hypertension and Adrenalectomy , Am. J. Physiol. 123:224, 1938. 18. Williams, J. R., Jr.; Diaz, J. T.; Burch, J. C., and Harrison, T. R.: Relation of Adrenal Glands to Action of Renal Pressor Substance , Am. J. M. Sc. 198:212, 1939. 19. Friedman, B.; Somkin, E., and Oppenheimer, E. T.: The Relation of Renin to the Adrenal Gland , Am. J. Physiol. 128:481, 1940. 20. Harrison, T. R.; Grollman, A., and Williams, J. R., Jr.: The Antipressor Action of Renal Extracts and Their Capacity to Reduce the Blood Pressure of Hypertensive Rats , Am. J. Physiol. 128:716, 1940. 21. Fasciolo, J. C.; Houssay, B. A., and Taquini, A. C.: The Blood-Pressure Raising Secretion of the Ischemic Kidney , J. Physiol. 94:281, 1938. 22. Mason, M. F., and Rozzell, J. D.: Attempts to Demonstrate Vasopressor Properties in the Serum of Hypertensive Dogs , Proc. Soc. Exper. Biol. & Med. 42:142, 1939. 23. Kohlstaedt, K. G.; Helmer, O. M., and Page, I. H.: Am. Heart J. , to be published. 24. Page, I. H., and Helmer, O. M.: Personal communication to the authors. 25. Page, I. H.: Personal communication to the authors. 26. Braun-Menendez, E.; Fasciolo, J. C.; Leloir, L. F., and Muñoz, J. M.: La substancia hypertensora de la sangre del riñón isquemiado , Rev. Soc. argent. de biol. 15:420, 1939. 27. Braun-Menendez, E., and Fasciolo, J. C.: Acción vasoconstrictora e hypertensora de la sangre venosa del riñón en isquemea incompleta aguda , Rev. Soc. argent. de biol. 15:161, 1939. 28. Kohlstaedt, Helmer and Page.16a 29. Page.16c 30. Dock, W., and Rytand, D. A.: Absence of Vasoconstrictor Substance in Blood of Rats with Renal Hypertension , Proc. Soc. Exper. Biol. & Med. 32: 374, 1934 31. Dock, W.: Personal communication to the authors. 32. Glenn, F.; Child, C. G., and Page, I. H.: The Effect of Destruction of the Spinal Cord on Hypertension Artificially Produced in Dogs , Am. J. Physiol. 122:506, 1938.
Archives of Internal Medicine – American Medical Association
Published: May 1, 1941
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