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PRESENT STATUS OF ATTENUATED LIVE-VIRUS POLIOMYELITIS VACCINE

PRESENT STATUS OF ATTENUATED LIVE-VIRUS POLIOMYELITIS VACCINE • Various studies, summarized here, have established beyond doubt that immunization of humans by the oral route of administration not only is possible but has been successfully accomplished. Since attenuated strains of poliovirus were found to vary greatly in the extent of their residual neurotropism for the most sensitive lower motor neurons as well as in the homogeneity of their populations, the crucial problem was to find strains that were so highly attenuated and homogeneous that one would be justifed in using them in increasingly larger numbers of humans in those stepwise tests that must precede any trial of such a vaccine on a large scale. The finding of such strains after tests on the progeny of large numbers of individual virus particles is here described. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

PRESENT STATUS OF ATTENUATED LIVE-VIRUS POLIOMYELITIS VACCINE

JAMA , Volume 162 (18) – Dec 29, 1956

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Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1956.02970350005002
Publisher site
See Article on Publisher Site

Abstract

• Various studies, summarized here, have established beyond doubt that immunization of humans by the oral route of administration not only is possible but has been successfully accomplished. Since attenuated strains of poliovirus were found to vary greatly in the extent of their residual neurotropism for the most sensitive lower motor neurons as well as in the homogeneity of their populations, the crucial problem was to find strains that were so highly attenuated and homogeneous that one would be justifed in using them in increasingly larger numbers of humans in those stepwise tests that must precede any trial of such a vaccine on a large scale. The finding of such strains after tests on the progeny of large numbers of individual virus particles is here described.

Journal

JAMAAmerican Medical Association

Published: Dec 29, 1956

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