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Presenile Cataracts

Presenile Cataracts Abstract To the Editor. —I read with great interest the article entitled "Presenile Cataracts in Phenytoin-Treated Epileptic Patients" by Bar et al in the March Archives (1983;101:422-425). The data they present from their rabbit experiments are certainly suggestive that cataract development, in rabbits, is hastened by treatment with phenytoin.It is unfortunate, however, that neither of the two human patients described in the article had blood drawn for galactose-1-phosphate uridyl transferase and galactokinase levels. It is important to eliminate heterozygosity for galactosemia as a cause of presenile cataract formation before any conclusions can be made with respect to the cataractogenic effect of a given drug.See the excellent article by Skalka and Prchal1 for a discussion of presenile cataract formation and decreased acuity of galactosemic enzymes. References 1. Skalka HW, Prchal JT: Presenile cataract formation and decreased activity of galactosemic enzymes . Arch Ophthalmol 1980;98:269-273.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Presenile Cataracts

Abstract

Abstract To the Editor. —I read with great interest the article entitled "Presenile Cataracts in Phenytoin-Treated Epileptic Patients" by Bar et al in the March Archives (1983;101:422-425). The data they present from their rabbit experiments are certainly suggestive that cataract development, in rabbits, is hastened by treatment with phenytoin.It is unfortunate, however, that neither of the two human patients described in the article had blood drawn for galactose-1-phosphate...
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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1984.01040030013008
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —I read with great interest the article entitled "Presenile Cataracts in Phenytoin-Treated Epileptic Patients" by Bar et al in the March Archives (1983;101:422-425). The data they present from their rabbit experiments are certainly suggestive that cataract development, in rabbits, is hastened by treatment with phenytoin.It is unfortunate, however, that neither of the two human patients described in the article had blood drawn for galactose-1-phosphate uridyl transferase and galactokinase levels. It is important to eliminate heterozygosity for galactosemia as a cause of presenile cataract formation before any conclusions can be made with respect to the cataractogenic effect of a given drug.See the excellent article by Skalka and Prchal1 for a discussion of presenile cataract formation and decreased acuity of galactosemic enzymes. References 1. Skalka HW, Prchal JT: Presenile cataract formation and decreased activity of galactosemic enzymes . Arch Ophthalmol 1980;98:269-273.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jan 1, 1984

References