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Prefrontal-Type Cognitive Deficits and Chronic Psychiatric Conditions

Prefrontal-Type Cognitive Deficits and Chronic Psychiatric Conditions Abstract To the Editor.— It is interesting to note that while the existence of dementia or cognitive deficits affecting chronic psychiatric patients is common anecdotal knowledge among psychiatrists, it has been very difficult to specify and quantify those deficits.In the November 1987 issue of the Archives, Goldberg et al1 presented data based on Wisconsin Card Sorting test (WCS) results reinforcing the hypothesis of prefrontal-type cognitive deficits in a group of chronic schizophrenics who were receiving neuroleptic drugs. Previously, Weinberger et al2,3 presented regional cerebral blood flow data as evidence of a physiologic dysfunction of dorsolateral prefrontal cortex also related to the performance on the WCS.Although the data presented by Goldberg et al1 and Weinberger et al2,3 were carefully obtained, one should always keep in mind that they studied patients with chronic conditions who had received or were receiving neuroleptic medication. Could similar data be obtained References 1. Goldberg TE, Weinberger DR, Berman KF, Pliskin NH, Podd MH: Further evidence for dementia of the prefrontal type in schizophrenia? A controlled study of teaching the Wisconsin Card Sorting Test . Arch Gen Psychiatry 1987;44:1008-1014.Crossref 2. Weinberger DR, Berman KF, Zec RF: Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia: I. Regional cerebral blood flow evidence . Arch Gen Psychiatry 1986;43:114-125.Crossref 3. Berman KF, Zec RF, Weinberger DR: Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia: II. Role of neuroleptic treatment, attention, and mental effort . Arch Gen Psychiatry 1986;43:126-135.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Prefrontal-Type Cognitive Deficits and Chronic Psychiatric Conditions

Archives of General Psychiatry , Volume 45 (11) – Nov 1, 1988

Prefrontal-Type Cognitive Deficits and Chronic Psychiatric Conditions

Abstract

Abstract To the Editor.— It is interesting to note that while the existence of dementia or cognitive deficits affecting chronic psychiatric patients is common anecdotal knowledge among psychiatrists, it has been very difficult to specify and quantify those deficits.In the November 1987 issue of the Archives, Goldberg et al1 presented data based on Wisconsin Card Sorting test (WCS) results reinforcing the hypothesis of prefrontal-type cognitive deficits in a group of chronic...
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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1988.01800350088017
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— It is interesting to note that while the existence of dementia or cognitive deficits affecting chronic psychiatric patients is common anecdotal knowledge among psychiatrists, it has been very difficult to specify and quantify those deficits.In the November 1987 issue of the Archives, Goldberg et al1 presented data based on Wisconsin Card Sorting test (WCS) results reinforcing the hypothesis of prefrontal-type cognitive deficits in a group of chronic schizophrenics who were receiving neuroleptic drugs. Previously, Weinberger et al2,3 presented regional cerebral blood flow data as evidence of a physiologic dysfunction of dorsolateral prefrontal cortex also related to the performance on the WCS.Although the data presented by Goldberg et al1 and Weinberger et al2,3 were carefully obtained, one should always keep in mind that they studied patients with chronic conditions who had received or were receiving neuroleptic medication. Could similar data be obtained References 1. Goldberg TE, Weinberger DR, Berman KF, Pliskin NH, Podd MH: Further evidence for dementia of the prefrontal type in schizophrenia? A controlled study of teaching the Wisconsin Card Sorting Test . Arch Gen Psychiatry 1987;44:1008-1014.Crossref 2. Weinberger DR, Berman KF, Zec RF: Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia: I. Regional cerebral blood flow evidence . Arch Gen Psychiatry 1986;43:114-125.Crossref 3. Berman KF, Zec RF, Weinberger DR: Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia: II. Role of neuroleptic treatment, attention, and mental effort . Arch Gen Psychiatry 1986;43:126-135.Crossref

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Nov 1, 1988

References