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Preexposure Prophylaxis

Preexposure Prophylaxis PrEP and Decreased Glomerular Filtration Rate Original Investigation Research Invited Commentary A Path Forward Mitchell H. Katz, MD Thirty years after the discovery of the human immunodefi- On the question of adverse effects, the article by Mugwanya ciency virus (HIV), about 50 000 Americans and over 2 mil- et al in this issue of JAMA Internal Medicine is reassuring. It lion persons worldwide are infected each year, most of them is known that tenofovir is associated with declining renal func- through sexual relations. tion when taken by HIV-infected patients, but is the same true This occurs despite detailed of healthy persons taking the medication for preexposure Related article page 246 knowledge of how HIV is prophylaxis? The authors found, in a population with high ad- transmitted and the availability of a highly effective, cheap, herence to preexposure prophylaxis, that decreases in esti- safe method of HIV prevention, the condom, which in addi- mated glomerular filtration rates were small and not progres- tion to its effectiveness in HIV prevention, also decreases the sive. While this is good news, it is important to note that the likelihood of other sexually transmitted diseases as well as un- length of follow-up was a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Internal Medicine American Medical Association

Preexposure Prophylaxis

JAMA Internal Medicine , Volume 175 (2) – Feb 1, 2015

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Publisher
American Medical Association
Copyright
Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6106
eISSN
2168-6114
DOI
10.1001/jamainternmed.2014.6798
pmid
25531165
Publisher site
See Article on Publisher Site

Abstract

PrEP and Decreased Glomerular Filtration Rate Original Investigation Research Invited Commentary A Path Forward Mitchell H. Katz, MD Thirty years after the discovery of the human immunodefi- On the question of adverse effects, the article by Mugwanya ciency virus (HIV), about 50 000 Americans and over 2 mil- et al in this issue of JAMA Internal Medicine is reassuring. It lion persons worldwide are infected each year, most of them is known that tenofovir is associated with declining renal func- through sexual relations. tion when taken by HIV-infected patients, but is the same true This occurs despite detailed of healthy persons taking the medication for preexposure Related article page 246 knowledge of how HIV is prophylaxis? The authors found, in a population with high ad- transmitted and the availability of a highly effective, cheap, herence to preexposure prophylaxis, that decreases in esti- safe method of HIV prevention, the condom, which in addi- mated glomerular filtration rates were small and not progres- tion to its effectiveness in HIV prevention, also decreases the sive. While this is good news, it is important to note that the likelihood of other sexually transmitted diseases as well as un- length of follow-up was a

Journal

JAMA Internal MedicineAmerican Medical Association

Published: Feb 1, 2015

References