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Prednisone Therapy for Alopecia Areata: A Follow-Up Report

Prednisone Therapy for Alopecia Areata: A Follow-Up Report Abstract • Eighteen patients treated with prednisone on alternate days for varying degrees of alopecia areata (AA) were examined a mean of 15 months after discontinuation of the drug. Despite an initial response to the therapy, long-term benefit was not thought to be substantial. Numerous side effects related either to systemic corticosteroids or to AA were apparent during the course of therapy, as well as at the time of the evaluation reported herein. Acne, obesity, lenticular opacities, mild hypertension, and impaired adrenocorticotropic hormone (ACTH) reserve were among the findings noted. Long-term treatment was not accompanied by an obvious beneficial change in the natural course of AA. Because of the potentially serious side effects and the lack of substantial improvement in the eventual course, alternate-day prednisone therapy is not recommended for long-term use in AA. (Arch Dermatol 112:1549-1552, 1976) References 1. Muller SA, Winkelmann RK: Alopecia areata . Arch Dermatol 88:290-297, 1963.Crossref 2. Van Scott EJ: Evaluation of disturbed hair growth in alopecia areata and other alopecias . Ann NY Acad Sci 83:480-490, 1959.Crossref 3. Ikeda T: A new classification of alopecia areata . Dermatologica 131:421-445, 1965.Crossref 4. Kern F, Hoffman W, Hambrick GW, et al: Alopecia areata: Immunologic studies and treatment with prednisone . Arch Dermatol 107:407-412, 1973.Crossref 5. Migeon CJ: Hypoadrenocorticism , in Kelly VC (ed): Metabolic, Endocrine, and Genetic Disorders of Children . New York, Harper and Row Publishers, Inc, 1974, pp 245-262. 6. Solomon IL, Blizzard RM: Autoimmune disorders of endocrine glands . J Pediatr 63:1021-1039, 1963.Crossref 7. Porter CC, Silber RH: A quantitative color reaction for cortisone and related 17, 21-dihydroxy-20-ketosteroids . J Biol Chem 185:201-207, 1950. 8. Greulich WW, Pyle SI: Radiographic Atlas of Skeletal Development of the Hand and Wrist , ed 2. Stanford, Calif, Stanford University Press, 1959. 9. Keenan BS, Beitins IZ, Lee PA, et al: Estimation of ACTH reserve on normal and hypopituitary subjects: Comparison of oral and intravenous metapyrone with insulin hypoglycemia . J Clin Endocrinol Metab 37:540-549, 1973.Crossref 10. Beitins IZ, Shaw MH, Kowarski A, et al: Comparison of competitive protein binding radioassay of cortisol to double isotope dilution and Porter-Silber Methods . Steroids 15:765-776, 1970.Crossref 11. Cunliffe WJ, Hall R, Stevenson CJ, et al: Alopecia areata, thyroid disease and autoimmunity . Br J Dermatol 81:877-881, 1969.Crossref 12. Klein U, Weinheimer B, Zaun H: Simultaneous occurrence of areata alopecia and immunothyroiditis . Int J Dermatol 13:116-118, 1974.Crossref 13. Dillaha CJ, Rothman S: Therapeutic experiments in alopecia areata with orally administered cortisone . JAMA 150:546-550, 1952.Crossref 14. Shelley WB, Harun JS, Lehman JM: Long-term triamcinolone therapy of alopecia universalis . Arch Dermatol 80:433-435, 1959.Crossref 15. Popchristov P, Konstantinov A, Obreshkova E: The blood vessels of the scalp in patients with alopecia areata before and after corticosteroid therapy . Br J Dermatol 80:753-757, 1968.Crossref 16. Martin MM, Gaboardi F, Podolsky S, et al: Intermittent steroid therapy . N Engl J Med 279:273-278, 1968.Crossref 17. Mac Gregor RR, Shegren JN, Lipsett MB, et al: Alternate day prednisone therapy . N Engl J Med 280:1427-1431, 1969.Crossref 18. Rabhan NB: Pituitary-adrenal suppression and cushing's syndrome after intermittent dexamethasone therapy . Ann Intern Med 69:1141-1148, 1968.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Prednisone Therapy for Alopecia Areata: A Follow-Up Report

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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1976.01630350025006
Publisher site
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Abstract

Abstract • Eighteen patients treated with prednisone on alternate days for varying degrees of alopecia areata (AA) were examined a mean of 15 months after discontinuation of the drug. Despite an initial response to the therapy, long-term benefit was not thought to be substantial. Numerous side effects related either to systemic corticosteroids or to AA were apparent during the course of therapy, as well as at the time of the evaluation reported herein. Acne, obesity, lenticular opacities, mild hypertension, and impaired adrenocorticotropic hormone (ACTH) reserve were among the findings noted. Long-term treatment was not accompanied by an obvious beneficial change in the natural course of AA. Because of the potentially serious side effects and the lack of substantial improvement in the eventual course, alternate-day prednisone therapy is not recommended for long-term use in AA. (Arch Dermatol 112:1549-1552, 1976) References 1. Muller SA, Winkelmann RK: Alopecia areata . Arch Dermatol 88:290-297, 1963.Crossref 2. Van Scott EJ: Evaluation of disturbed hair growth in alopecia areata and other alopecias . Ann NY Acad Sci 83:480-490, 1959.Crossref 3. Ikeda T: A new classification of alopecia areata . Dermatologica 131:421-445, 1965.Crossref 4. Kern F, Hoffman W, Hambrick GW, et al: Alopecia areata: Immunologic studies and treatment with prednisone . Arch Dermatol 107:407-412, 1973.Crossref 5. Migeon CJ: Hypoadrenocorticism , in Kelly VC (ed): Metabolic, Endocrine, and Genetic Disorders of Children . New York, Harper and Row Publishers, Inc, 1974, pp 245-262. 6. Solomon IL, Blizzard RM: Autoimmune disorders of endocrine glands . J Pediatr 63:1021-1039, 1963.Crossref 7. Porter CC, Silber RH: A quantitative color reaction for cortisone and related 17, 21-dihydroxy-20-ketosteroids . J Biol Chem 185:201-207, 1950. 8. Greulich WW, Pyle SI: Radiographic Atlas of Skeletal Development of the Hand and Wrist , ed 2. Stanford, Calif, Stanford University Press, 1959. 9. Keenan BS, Beitins IZ, Lee PA, et al: Estimation of ACTH reserve on normal and hypopituitary subjects: Comparison of oral and intravenous metapyrone with insulin hypoglycemia . J Clin Endocrinol Metab 37:540-549, 1973.Crossref 10. Beitins IZ, Shaw MH, Kowarski A, et al: Comparison of competitive protein binding radioassay of cortisol to double isotope dilution and Porter-Silber Methods . Steroids 15:765-776, 1970.Crossref 11. Cunliffe WJ, Hall R, Stevenson CJ, et al: Alopecia areata, thyroid disease and autoimmunity . Br J Dermatol 81:877-881, 1969.Crossref 12. Klein U, Weinheimer B, Zaun H: Simultaneous occurrence of areata alopecia and immunothyroiditis . Int J Dermatol 13:116-118, 1974.Crossref 13. Dillaha CJ, Rothman S: Therapeutic experiments in alopecia areata with orally administered cortisone . JAMA 150:546-550, 1952.Crossref 14. Shelley WB, Harun JS, Lehman JM: Long-term triamcinolone therapy of alopecia universalis . Arch Dermatol 80:433-435, 1959.Crossref 15. Popchristov P, Konstantinov A, Obreshkova E: The blood vessels of the scalp in patients with alopecia areata before and after corticosteroid therapy . Br J Dermatol 80:753-757, 1968.Crossref 16. Martin MM, Gaboardi F, Podolsky S, et al: Intermittent steroid therapy . N Engl J Med 279:273-278, 1968.Crossref 17. Mac Gregor RR, Shegren JN, Lipsett MB, et al: Alternate day prednisone therapy . N Engl J Med 280:1427-1431, 1969.Crossref 18. Rabhan NB: Pituitary-adrenal suppression and cushing's syndrome after intermittent dexamethasone therapy . Ann Intern Med 69:1141-1148, 1968.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1976

References