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Predictive Marker for the Development of Cerebral Toxoplasmosis in Patients With Human Immunodeficiency Virus Type 1

Predictive Marker for the Development of Cerebral Toxoplasmosis in Patients With Human... Abstract Patients admitted with cerebral toxoplasmosis tend to respond poorly to antitoxoplasmic drug therapy; therefore, primary prophylaxis for patients at high risk would seem attractive. Primary prophylaxis with trimethoprim-sulfamethoxazole against cerebral toxoplasmosis has recently been shown to be efficacious.1 However, long-term therapy with antitoxoplasmic drugs has frequent side effects; patients with a low risk of developing cerebral toxoplasmosis may not benefit from primary prophylaxis. In a retrospective analysis of the patients seen in our center between January 1, 1986, and June 1, 1992, we tried to find predictors of subsequent Toxoplasma encephalitis. Only patients with no clinical indications of neuropsychiatric disturbances and computed tomographic or magnetic resonance imaging scans showing no focal lesions were included in the study. All patients underwent complete clinical examination, lumbar puncture, and computed tomographic scanning at intervals of 6 months. All 45 patients who were eligible for the longitudinal observation were homosexual men, with a References 1. Carr A, Tindall B, Brew BJ, et al. Low-dose trimethoprim-sulfamethoxazole prophylaxis for toxoplasmic encephalitis in patients with AIDS . Ann Intern Med . 1992;117:106-111.Crossref 2. Redfield RR, Wright DC, Tramont EC. The Walter Reed Staging Classification for HTLV III/LAV infection . N Engl J Med . 1986;314:131-132.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Predictive Marker for the Development of Cerebral Toxoplasmosis in Patients With Human Immunodeficiency Virus Type 1

Archives of Neurology , Volume 52 (3) – Mar 1, 1995

Predictive Marker for the Development of Cerebral Toxoplasmosis in Patients With Human Immunodeficiency Virus Type 1

Abstract

Abstract Patients admitted with cerebral toxoplasmosis tend to respond poorly to antitoxoplasmic drug therapy; therefore, primary prophylaxis for patients at high risk would seem attractive. Primary prophylaxis with trimethoprim-sulfamethoxazole against cerebral toxoplasmosis has recently been shown to be efficacious.1 However, long-term therapy with antitoxoplasmic drugs has frequent side effects; patients with a low risk of developing cerebral toxoplasmosis may not benefit from primary...
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Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1995.00540270015003
Publisher site
See Article on Publisher Site

Abstract

Abstract Patients admitted with cerebral toxoplasmosis tend to respond poorly to antitoxoplasmic drug therapy; therefore, primary prophylaxis for patients at high risk would seem attractive. Primary prophylaxis with trimethoprim-sulfamethoxazole against cerebral toxoplasmosis has recently been shown to be efficacious.1 However, long-term therapy with antitoxoplasmic drugs has frequent side effects; patients with a low risk of developing cerebral toxoplasmosis may not benefit from primary prophylaxis. In a retrospective analysis of the patients seen in our center between January 1, 1986, and June 1, 1992, we tried to find predictors of subsequent Toxoplasma encephalitis. Only patients with no clinical indications of neuropsychiatric disturbances and computed tomographic or magnetic resonance imaging scans showing no focal lesions were included in the study. All patients underwent complete clinical examination, lumbar puncture, and computed tomographic scanning at intervals of 6 months. All 45 patients who were eligible for the longitudinal observation were homosexual men, with a References 1. Carr A, Tindall B, Brew BJ, et al. Low-dose trimethoprim-sulfamethoxazole prophylaxis for toxoplasmic encephalitis in patients with AIDS . Ann Intern Med . 1992;117:106-111.Crossref 2. Redfield RR, Wright DC, Tramont EC. The Walter Reed Staging Classification for HTLV III/LAV infection . N Engl J Med . 1986;314:131-132.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Mar 1, 1995

References