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Prediction of Proliferative Diabetic Retinopathy With Hemoglobin Level

Prediction of Proliferative Diabetic Retinopathy With Hemoglobin Level EPIDEMIOLOGY Prediction of Proliferative Diabetic Retinopathy With Hemoglobin Level Baqiyyah N. Conway, PhD; Rachel G. Miller, MS; Ronald Klein, MD; Trevor J. Orchard, MD Objective: To investigate the role of hemoglobin (HGB) women), in men, HGB exhibited a positive linear rela- level in predicting proliferative diabetic retinopathy (PDR). tionship with 18-year incidence of PDR (hazard ra- tio, 1.33; 95% confidence interval, 1.10-1.60; P = .003), Methods: We assessed 426 individuals without PDR at while in women, HGB level exhibited a quadratic rela- baseline (213 men; 213 women) from the Pittsburgh Epi- tionship with PDR (P .001). After multivariable adjust- demiology of Diabetes Complications Study, an 18-year ment for univariately significant covariates, HGB level re- prospective cohort study of childhood-onset type 1 dia- mained significantly predictive of PDR in both men betes. Presence of PDR was determined by stereo fun- (P = .004) and women (P = .04). dus photography. Cox proportional hazards modeling with stepwise regression was used to determine the in- Conclusion: Higher HGB level predicts the incidence of dependent association of HGB level with PDR. Analyses PDR in type 1 diabetes mellitus, though the association were sex specific. varies by sex, being linear and positive in men http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

Prediction of Proliferative Diabetic Retinopathy With Hemoglobin Level

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References (58)

Publisher
American Medical Association
Copyright
Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6165
eISSN
2168-6173
DOI
10.1001/archophthalmol.2009.274
pmid
19901215
Publisher site
See Article on Publisher Site

Abstract

EPIDEMIOLOGY Prediction of Proliferative Diabetic Retinopathy With Hemoglobin Level Baqiyyah N. Conway, PhD; Rachel G. Miller, MS; Ronald Klein, MD; Trevor J. Orchard, MD Objective: To investigate the role of hemoglobin (HGB) women), in men, HGB exhibited a positive linear rela- level in predicting proliferative diabetic retinopathy (PDR). tionship with 18-year incidence of PDR (hazard ra- tio, 1.33; 95% confidence interval, 1.10-1.60; P = .003), Methods: We assessed 426 individuals without PDR at while in women, HGB level exhibited a quadratic rela- baseline (213 men; 213 women) from the Pittsburgh Epi- tionship with PDR (P .001). After multivariable adjust- demiology of Diabetes Complications Study, an 18-year ment for univariately significant covariates, HGB level re- prospective cohort study of childhood-onset type 1 dia- mained significantly predictive of PDR in both men betes. Presence of PDR was determined by stereo fun- (P = .004) and women (P = .04). dus photography. Cox proportional hazards modeling with stepwise regression was used to determine the in- Conclusion: Higher HGB level predicts the incidence of dependent association of HGB level with PDR. Analyses PDR in type 1 diabetes mellitus, though the association were sex specific. varies by sex, being linear and positive in men

Journal

JAMA Ophthalmology – American Medical Association

Published: Nov 1, 2009

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