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Predicting Early Hepatic Graft Failure—The Quest Continues

Predicting Early Hepatic Graft Failure—The Quest Continues Predicting Early Hepatic Graft Failure Invited Commentary Invited Commentary Ronald W. Busuttil, MD, PhD Beginning with the pioneering experimental liver trans- Liver Disease (MELD) score, blood transfusion, and early plants by Vittorio Staudacher and eventually the successful thrombosis of hepatic vessels and appears to have stronger human liver transplant by Thomas Starzl, the remarkable ad- estimation power compared with previously reported mod- vances in liver transplant have made it a highly durable, eling systems. As with most modeling systems, there are live-saving, and quality of some areas of clinical incongruence. In addition to the lack life–restoring operation. This of clinically relevant donor data such as graft steatosis or Related article data on reperfusion injury or vascular thrombosis, certainly success has created a tremen- dous demand for organs to save the lives of thousands of pa- an important factor incorporated in the EASE score is not tients annually. A record 8896 liver transplants were per- substratified into portal vein vs hepatic arterial thrombosis. formed in the United States in 2019, an increase driven largely This is quite relevant because the physiologic insult to the by more aggressive use of marginal organs. Of these trans- graft and its timeline are quite http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Surgery American Medical Association

Predicting Early Hepatic Graft Failure—The Quest Continues

Busuttil, Ronald W.
JAMA Surgery , Volume 155 (12) – Dec 28, 2020
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Predicting Early Hepatic Graft Failure—The Quest Continues

Abstract

Predicting Early Hepatic Graft Failure Invited Commentary Invited Commentary Ronald W. Busuttil, MD, PhD Beginning with the pioneering experimental liver trans- Liver Disease (MELD) score, blood transfusion, and early plants by Vittorio Staudacher and eventually the successful thrombosis of hepatic vessels and appears to have stronger human liver transplant by Thomas Starzl, the remarkable ad- estimation power compared with previously reported mod- vances in liver transplant have made it a...
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Publisher
American Medical Association
Copyright
Copyright 2020 American Medical Association. All Rights Reserved.
ISSN
2168-6254
eISSN
2168-6262
DOI
10.1001/jamasurg.2020.4593
Publisher site
See Article on Publisher Site

Abstract

Predicting Early Hepatic Graft Failure Invited Commentary Invited Commentary Ronald W. Busuttil, MD, PhD Beginning with the pioneering experimental liver trans- Liver Disease (MELD) score, blood transfusion, and early plants by Vittorio Staudacher and eventually the successful thrombosis of hepatic vessels and appears to have stronger human liver transplant by Thomas Starzl, the remarkable ad- estimation power compared with previously reported mod- vances in liver transplant have made it a highly durable, eling systems. As with most modeling systems, there are live-saving, and quality of some areas of clinical incongruence. In addition to the lack life–restoring operation. This of clinically relevant donor data such as graft steatosis or Related article data on reperfusion injury or vascular thrombosis, certainly success has created a tremen- dous demand for organs to save the lives of thousands of pa- an important factor incorporated in the EASE score is not tients annually. A record 8896 liver transplants were per- substratified into portal vein vs hepatic arterial thrombosis. formed in the United States in 2019, an increase driven largely This is quite relevant because the physiologic insult to the by more aggressive use of marginal organs. Of these trans- graft and its timeline are quite

Journal

JAMA Surgery – American Medical Association

Published: Dec 28, 2020

References

  • The first report of orthotopic liver transplantation in the Western world
    Busuttil, RW; De Carlis, LG; Mihaylov, PV; Gridelli, B; Fassati, LR; Starzl, TE
  • Orthotopic homotransplantation of the human liver
    Starzl, TE; Groth, CG; Brettschneider, L
  • Development and validation of a comprehensive model to estimate early allograft failure among patients requiring early liver retransplant
    Avolio, AW; Franco, A; Schlegel, A
  • Evaluation of early allograft function using the Liver Graft Assessment Following Transplantation risk score model
    Agopian, VG; Harlander-Locke, MP; Markovic, D
  • Predictive index for long-term survival after retransplantation of the liver in adult recipients: analysis of a 26-year experience in a single center
    Hong, JC; Kaldas, FM; Kositamongkol, P
  • A randomized trial of normothermic preservation in liver transplantation
    Nasralla, D; Coussios, CC; Mergental, H