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Precipitous Mental Deterioration Following Cycloplegia With 0.2% Cyclopentolate HC1

Precipitous Mental Deterioration Following Cycloplegia With 0.2% Cyclopentolate HC1 Abstract Following instillation of four drops of a solution of 0.2% cyclopentolate hydrochloride, 1% phenylephrine hydrochloride, with 3% polyvinylpyrrolidone in buffered isotonic base with 0.5% chlorbutanol as a preservative (cyclomydril), an 82-year-old man showed a decompensation of a previously compensated chronic dementia. It is postulated that he became delirious as reported in other cases following administration of 1% or 2% cyclopentolate. Further, his failure to recover the status quo ante was felt to represent a more general phenomenon; namely, the inability to regain coping mechanisms established at a time when the mental apparatus was capable of a higher order of function. References 1. Beswick, J.A.: Psychosis From Cyclopentolate , Amer J Ophthal 53:879-880 ( (May) ) 1962. 2. Binkhorst, R.D., et al: Psychotic Reactions Induced by Cyclopentolate (Cyclogyl) , Amer J Ophthal 55:1243-1245 ( (June) ) 1963. 3. Mach, H.H.: Psychosis and Cyclopentolates , JAMA 186:430-431 ( (Oct 26) ) 1963.Crossref 4. Praeger, D.L., and Miller, S.N.: Toxic Effects of Cyclopentolate (Cyclogyl) , Amer J Ophthal 58:1060-1061 ( (Dec) ) 1964. 5. Simcoe, C.W.: Cyclopentolate (Cyclogyl) Toxicity: Report of a Case , Arch Ophthal 67:406-408 ( (April) ) 1962.Crossref 6. Hoefnagel, D.: Toxic Effects of Atropine and Homatropine Eyedrops in Children , New Eng J Med 264:168-171 ( (Jan 26) ) 1961.Crossref 7. Ziskind, E.: An Explanation of Mental Symptoms Found in Acute Sensory Deprivation, Researches, 1958-63 , Amer J Psychiat 121:939-946 ( (April) ) 1965. 8. Ehrenwald, J.: Visual Distortion Test , Arch Gen Psychiat 7:30-38, 1962.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Precipitous Mental Deterioration Following Cycloplegia With 0.2% Cyclopentolate HC1

Archives of Ophthalmology , Volume 78 (4) – Oct 1, 1967

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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1967.00980030447006
Publisher site
See Article on Publisher Site

Abstract

Abstract Following instillation of four drops of a solution of 0.2% cyclopentolate hydrochloride, 1% phenylephrine hydrochloride, with 3% polyvinylpyrrolidone in buffered isotonic base with 0.5% chlorbutanol as a preservative (cyclomydril), an 82-year-old man showed a decompensation of a previously compensated chronic dementia. It is postulated that he became delirious as reported in other cases following administration of 1% or 2% cyclopentolate. Further, his failure to recover the status quo ante was felt to represent a more general phenomenon; namely, the inability to regain coping mechanisms established at a time when the mental apparatus was capable of a higher order of function. References 1. Beswick, J.A.: Psychosis From Cyclopentolate , Amer J Ophthal 53:879-880 ( (May) ) 1962. 2. Binkhorst, R.D., et al: Psychotic Reactions Induced by Cyclopentolate (Cyclogyl) , Amer J Ophthal 55:1243-1245 ( (June) ) 1963. 3. Mach, H.H.: Psychosis and Cyclopentolates , JAMA 186:430-431 ( (Oct 26) ) 1963.Crossref 4. Praeger, D.L., and Miller, S.N.: Toxic Effects of Cyclopentolate (Cyclogyl) , Amer J Ophthal 58:1060-1061 ( (Dec) ) 1964. 5. Simcoe, C.W.: Cyclopentolate (Cyclogyl) Toxicity: Report of a Case , Arch Ophthal 67:406-408 ( (April) ) 1962.Crossref 6. Hoefnagel, D.: Toxic Effects of Atropine and Homatropine Eyedrops in Children , New Eng J Med 264:168-171 ( (Jan 26) ) 1961.Crossref 7. Ziskind, E.: An Explanation of Mental Symptoms Found in Acute Sensory Deprivation, Researches, 1958-63 , Amer J Psychiat 121:939-946 ( (April) ) 1965. 8. Ehrenwald, J.: Visual Distortion Test , Arch Gen Psychiat 7:30-38, 1962.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Oct 1, 1967

References