Abstract DURING the course of a project1 on the use of penicillin in the treatment of chronic osteomyelitis, recommended by the Committee on Medical Research and contracted for by the office of Scientific Research and Development with the Hospital for Joint Diseases, the opportunity arose for the initiation and the subsequent development of several collateral studies. All these were briefly discussed in the report2 submitted at the official termination of the project, and others3 were subsequently reported with additional data in greater detail. This paper concerns itself with the use of penicillin as a precautionary measure against infection during the course of surgical procedures with primary closures of the wounds of bones and joints on (1) patients without osteomyelitic lesions, (2) patients with inactive osteomyelitic lesions, (3) patients with active infections and (4) patients with postoperative infections. These studies were closely coordinated with studies on the bacteriologic status References 1. Buchman, J., and Blair, J. E.: Penicillin in the Treatment of Chronic Osteomyelitis: A Preliminary Report , Arch. Surg. 51:81-92 ( (Sept.) ) 1945.Crossref 2. Buchman, J., and Blair, J. E.: Report on the Use of Penicillin in the Treatment of Staphylococcal Infections with Special Reference to Acute and Chronic Osteomyelitis and Several Collateral Studies , Bull. Hosp. Joint Dis. 6:114-125 ( (Oct.) ) 1945. 3. Blair, J. E.; Carr, M., and Buchman, J.: The Action of Penicillin on Staphylococci , J. Immunol. 52:281-292 ( (Nov.) ) 1946. 4. Buchman, J., and Blair, J. E.: The Use of Absorbable Substances to Obliterate Bone Cavities and as Hemostatic Agents in Bone and Joint Conditions, J. Bone & Joint Surg., to be published. 5. Buchman and Blair (footnotes 1 and 2).
Archives of Surgery – American Medical Association
Published: Dec 1, 1947