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Potentiation of Amitriptyline by Thyroid Hormone

Potentiation of Amitriptyline by Thyroid Hormone Abstract A double-blind comparison was made between amitriptyline alone and amitriptyline with added L-triiodothyronine (T3, liothyronine sodium at two dose levels, in cases of depression seen in general practice. Assessments were made initially, and at 3, 7, 10, 14, and 21 days, using Hamilton's Depression Scales and the NIMH Self-Rating Scales. Significant differences in favor of the two regimes with added liothyronine were obtained at 14 days on both scales (P < .01) and on the Self-Rating Scales at ten days (P < .05). Results were better with the higher dose of liothyronine, particularly in females where the difference was significant at three days (P < .05). References 1. Asher R: Myxoedematous madness , Brit Med J 2:555-562, 1949.Crossref 2. Dewhurst KE, El Kabir DJ, Harris GW, et al: Observations on the blood concentration of thyrotropic hormone (TSH) in schizophrena and affective states . Brit J Psychiat 115:1003-1011, 1969.Crossref 3. Prange AJ Jr: Paroxysmal auricular tachycardia apparently resulting from combined thyroid-imipramine treatment . Amer J Psychiat 119:994-995, 1963. 4. Prange AJ Jr, Lipton MA: Enhancement of imipramine mortality in hyperthyroid mice . Nature 156:588-589, 1962.Crossref 5. Prange AJ Jr, Wilson IC, Rabon AM, and et al: Enhancement of imipraminne by triiodothyronine in unselected depressed patients, in The Present Status of Psychotropic Drugs: Proceedings of the Sixth International Congress of the Collegium Internationale Neuro-Pharmacologicum, Tarragona, Spain, 1968. Amsterdam, Excerpta Medica Foundation, International Congress Series No. 180, 1969 pp 532-535. 6. Prange AJ Jr, Wilson IC, Rabon AM, et al: Enhancement of imipramine antidepressant activity by thyroid hormone . Amer J Psychiat 126:457-469, 1969. 7. Wheatley D: Evaluation of psychotherapeutic drugs in general practice . Psychopharmacol Service Center Bull 2:25-31, 1962. 8. Wheatley D: A comparative trial of imipramine and phenobarbital in depressed patients seen in general practice . J Nerv Ment Dis 148:542-549, 1969.Crossref 9. Wheatley D: Comparative trial of a new monoamine oxidase inhibitor in depression . Brit J Psychiat 117:573-574, 1970.Crossref 10. General Practitioner Clinical Trials: Protriptyline in depression . Practitioner 201:506-509, 1968. 11. General Practitioner Clinical Trials: Two new psychotropic drugs: 1. A new antidepressant . Practitioner 198:135-139, 1967. 12. Wheatley D: Drug insufficiencies in the treatment of neurotic illness, in The Present Status of Psychotropic Drugs: Proceedings of the Sixth International Congress of the Collegium Internationale Neuro-Psychopharmacologium, Tarragona, Spain, 1968. Amsterdam, Excerpta Medica Foundation, International Congress Series No. 180, 1969, pp 556-558. 13. Lipman RS, Covi, L, Rickels K, et al: Selected measures of change in out-patient drug evaluation. Read before the American College of Neuropsychopharmacology, San Juan, Puerto Rico, 1967. 14. Williams HV, Lipman RS, Rickels K, et al: Replication of symptom distress factors in anxious neurotic out-patients . Mult Behav Res 3:199-212, 1968.Crossref 15. Wheatley D: Anticipation of response to treatment in domiciliary practice , in Wittenborn, Goldberg, May, (eds): Psychopharmacology and the Individual Patient . New York, Raven Press, 1970. 16. Prange AJ Jr, Coppen A, Whybrow PC: The comparative antidepressant value of L-tryptophan and imipramine, with and without attempted potentiation by triiodothyronine. Read before the Seventh Collegium Internationale Neuro-Psychopharmacologicum Meeting, Prague, 1970. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Potentiation of Amitriptyline by Thyroid Hormone

Archives of General Psychiatry , Volume 26 (3) – Mar 1, 1972

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Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1972.01750210037008
Publisher site
See Article on Publisher Site

Abstract

Abstract A double-blind comparison was made between amitriptyline alone and amitriptyline with added L-triiodothyronine (T3, liothyronine sodium at two dose levels, in cases of depression seen in general practice. Assessments were made initially, and at 3, 7, 10, 14, and 21 days, using Hamilton's Depression Scales and the NIMH Self-Rating Scales. Significant differences in favor of the two regimes with added liothyronine were obtained at 14 days on both scales (P < .01) and on the Self-Rating Scales at ten days (P < .05). Results were better with the higher dose of liothyronine, particularly in females where the difference was significant at three days (P < .05). References 1. Asher R: Myxoedematous madness , Brit Med J 2:555-562, 1949.Crossref 2. Dewhurst KE, El Kabir DJ, Harris GW, et al: Observations on the blood concentration of thyrotropic hormone (TSH) in schizophrena and affective states . Brit J Psychiat 115:1003-1011, 1969.Crossref 3. Prange AJ Jr: Paroxysmal auricular tachycardia apparently resulting from combined thyroid-imipramine treatment . Amer J Psychiat 119:994-995, 1963. 4. Prange AJ Jr, Lipton MA: Enhancement of imipramine mortality in hyperthyroid mice . Nature 156:588-589, 1962.Crossref 5. Prange AJ Jr, Wilson IC, Rabon AM, and et al: Enhancement of imipraminne by triiodothyronine in unselected depressed patients, in The Present Status of Psychotropic Drugs: Proceedings of the Sixth International Congress of the Collegium Internationale Neuro-Pharmacologicum, Tarragona, Spain, 1968. Amsterdam, Excerpta Medica Foundation, International Congress Series No. 180, 1969 pp 532-535. 6. Prange AJ Jr, Wilson IC, Rabon AM, et al: Enhancement of imipramine antidepressant activity by thyroid hormone . Amer J Psychiat 126:457-469, 1969. 7. Wheatley D: Evaluation of psychotherapeutic drugs in general practice . Psychopharmacol Service Center Bull 2:25-31, 1962. 8. Wheatley D: A comparative trial of imipramine and phenobarbital in depressed patients seen in general practice . J Nerv Ment Dis 148:542-549, 1969.Crossref 9. Wheatley D: Comparative trial of a new monoamine oxidase inhibitor in depression . Brit J Psychiat 117:573-574, 1970.Crossref 10. General Practitioner Clinical Trials: Protriptyline in depression . Practitioner 201:506-509, 1968. 11. General Practitioner Clinical Trials: Two new psychotropic drugs: 1. A new antidepressant . Practitioner 198:135-139, 1967. 12. Wheatley D: Drug insufficiencies in the treatment of neurotic illness, in The Present Status of Psychotropic Drugs: Proceedings of the Sixth International Congress of the Collegium Internationale Neuro-Psychopharmacologium, Tarragona, Spain, 1968. Amsterdam, Excerpta Medica Foundation, International Congress Series No. 180, 1969, pp 556-558. 13. Lipman RS, Covi, L, Rickels K, et al: Selected measures of change in out-patient drug evaluation. Read before the American College of Neuropsychopharmacology, San Juan, Puerto Rico, 1967. 14. Williams HV, Lipman RS, Rickels K, et al: Replication of symptom distress factors in anxious neurotic out-patients . Mult Behav Res 3:199-212, 1968.Crossref 15. Wheatley D: Anticipation of response to treatment in domiciliary practice , in Wittenborn, Goldberg, May, (eds): Psychopharmacology and the Individual Patient . New York, Raven Press, 1970. 16. Prange AJ Jr, Coppen A, Whybrow PC: The comparative antidepressant value of L-tryptophan and imipramine, with and without attempted potentiation by triiodothyronine. Read before the Seventh Collegium Internationale Neuro-Psychopharmacologicum Meeting, Prague, 1970.

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Mar 1, 1972

References