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ORIGINAL INVESTIGATION LESS IS MORE Potentially Inappropriate Medications Defined by STOPP Criteria and the Risk of Adverse Drug Events in Older Hospitalized Patients Hilary Hamilton, MB, MRCPI; Paul Gallagher, PhD, MRCPI; Cristin Ryan, PhD, MPSI; Stephen Byrne, PhD, MPSI; Denis O’Mahony, MD, FRCPI Background: Previous studies have not demonstrated and STOPP criteria PIMs with avoidable ADEs that were a consistent association between potentially inappropri- causal or contributory to admission. ate medicines (PIMs) in older patients as defined by Beers Results: A total of 329 ADEs were detected in 158 of 600 criteria and avoidable adverse drug events (ADEs). This patients (26.3%); 219 of 329 ADEs (66.6%) were consid- study aimed to assess whether PIMs defined by new ered causal or contributory to admission. Of the 219 ADEs, STOPP (Screening Tool of Older Persons’ potentially in- 151(68.9%)consideredcausalorcontributorytoadmission appropriate Prescriptions) criteria are significantly as- were avoidable or potentially avoidable. After adjusting for sociated with ADEs in older people with acute illness. age, sex, comorbidity, dementia, baseline activities of daily living function, and number of medications, the likelihood Methods: We prospectively studied 600 consecutive pa- of a serious avoidable ADE increased significantly when tients 65 years or older who were admitted with
JAMA Internal Medicine – American Medical Association
Published: Jun 13, 2011
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