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Potential Dangers of Radiation, Steroids Examined

Potential Dangers of Radiation, Steroids Examined Thirty-one survivors among a group of infants irradiated for various therapeutic reasons between 1940 and 1959 were examined by Harold Katzman, MD, and Columbia-Presbyterian Medical Center colleagues. Fifteen had undergone nephrectomy followed by irradiation for Wilm's tumor; 13 had been treated for neuroblastoma. Three patients with other diseases also were included because of "extremely interesting post-irradiation changes." All of the children examined showed skeletal changes with growth. Six needed orthopedic treatment. Average radiation dose to bone was calculated at 2,850 roentgens over 28 days. One of the children had been given an 8,000 r betatron dose for bilateral retinoblastoma. 'Bones Within Bones' Altered vertebral development was found in 23 of the 28 Wilm's tumor or neuroblastoma patients. Within the first post-radiation year, "bones within bones" were evident. This, Dr. Katzman explained probably represents epiphyseal growth arrest of endochondral ossification. Twenty of the 28 developed varying degrees of scoliosis, usually concave http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Potential Dangers of Radiation, Steroids Examined

JAMA , Volume 195 (7) – Feb 14, 1966

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1966.03100070021008
Publisher site
See Article on Publisher Site

Abstract

Thirty-one survivors among a group of infants irradiated for various therapeutic reasons between 1940 and 1959 were examined by Harold Katzman, MD, and Columbia-Presbyterian Medical Center colleagues. Fifteen had undergone nephrectomy followed by irradiation for Wilm's tumor; 13 had been treated for neuroblastoma. Three patients with other diseases also were included because of "extremely interesting post-irradiation changes." All of the children examined showed skeletal changes with growth. Six needed orthopedic treatment. Average radiation dose to bone was calculated at 2,850 roentgens over 28 days. One of the children had been given an 8,000 r betatron dose for bilateral retinoblastoma. 'Bones Within Bones' Altered vertebral development was found in 23 of the 28 Wilm's tumor or neuroblastoma patients. Within the first post-radiation year, "bones within bones" were evident. This, Dr. Katzman explained probably represents epiphyseal growth arrest of endochondral ossification. Twenty of the 28 developed varying degrees of scoliosis, usually concave

Journal

JAMAAmerican Medical Association

Published: Feb 14, 1966

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