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Potential Benefits of Early Aggressive Treatment in Multiple Sclerosis

Potential Benefits of Early Aggressive Treatment in Multiple Sclerosis Opinion Editorial Potential Benefits of Early Aggressive Treatment in Multiple Sclerosis Ari J. Green, MD, MCR “Our doubts are traitors, used an extraordinarily large international data set, MSBase, and make us lose the good we oft might win, headquartered in Melbourne, Australia. A major advantage of by fearing to attempt.” this data set is that it uses a standardized definition of what William Shakespeare, Measure for Measure constitutes secondary progressive disease to compare time to secondary progression for patients taking different MS thera- “Optimism, not pessimism, is needed in medicine; not, however, the pies. The results were clear. Nearly all agents appeared to have optimism that takes up each new fad to the exclusion of old and tried a measurable, favorable effect on disease progression. More- measures, but the kind that begets hopefulness and confidence.” over, the group of therapies that was most effective at decreas- Minor Comments. JAMA. 1901: 36 ing relapse rates also had the greatest benefit on disease pro- The brain is arguably the most precious organ in the body. gression. Furthermore, earlier initiation of these therapies Yet neurologists have a reputation for cautious implementa- uniformly appeared to have a more significant effect on dis- tion http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

Potential Benefits of Early Aggressive Treatment in Multiple Sclerosis

JAMA Neurology , Volume 76 (3) – Mar 15, 2019

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Publisher
American Medical Association
Copyright
Copyright 2019 American Medical Association. All Rights Reserved.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/jamaneurol.2018.4932
Publisher site
See Article on Publisher Site

Abstract

Opinion Editorial Potential Benefits of Early Aggressive Treatment in Multiple Sclerosis Ari J. Green, MD, MCR “Our doubts are traitors, used an extraordinarily large international data set, MSBase, and make us lose the good we oft might win, headquartered in Melbourne, Australia. A major advantage of by fearing to attempt.” this data set is that it uses a standardized definition of what William Shakespeare, Measure for Measure constitutes secondary progressive disease to compare time to secondary progression for patients taking different MS thera- “Optimism, not pessimism, is needed in medicine; not, however, the pies. The results were clear. Nearly all agents appeared to have optimism that takes up each new fad to the exclusion of old and tried a measurable, favorable effect on disease progression. More- measures, but the kind that begets hopefulness and confidence.” over, the group of therapies that was most effective at decreas- Minor Comments. JAMA. 1901: 36 ing relapse rates also had the greatest benefit on disease pro- The brain is arguably the most precious organ in the body. gression. Furthermore, earlier initiation of these therapies Yet neurologists have a reputation for cautious implementa- uniformly appeared to have a more significant effect on dis- tion

Journal

JAMA NeurologyAmerican Medical Association

Published: Mar 15, 2019

References