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Positive Nikolsky's and Bulla-Spread Signs in Acute Bullous Lichen Planus

Positive Nikolsky's and Bulla-Spread Signs in Acute Bullous Lichen Planus Abstract To the Editor.— Nikolsky's and bulla-spread signs, originally described by Pyotr Vasilyevich Nikolsky1,2 and G. Asboe-Hansen3 have proved to be reliable diagnostic tests. Although once thought to be the sine qua non of pemphigus, these signs are also elicited in staphylococcal scalded skin syndrome, adult toxic epidermal necrolysis, and certain hereditary blistering diseases.4 We examined a patient with acute generalized lichen planus with bullae in whom these signs were demonstrated. We would like to share our experience through this communication. Report of a Case.— Intensely itchy, erythematous, violaceous lesions developed over the feet and legs of a 40-year-old woman. One month later, the lesions progressed over a span of two weeks to involve her whole body. Large blisters and vesicles appeared overlying the preexisting lesions on the sites of friction over her legs, knees, buttocks, and back, and painful ulcers developed. There was pain and discomfort when References 1. Arndt KA, Feingold DS: The sign of Pyotr Vasilyevich Nikolsky . N Engl J Med 1970;282:1154-1155.Crossref 2. Goodman H: Nikolsky's sign . Arch Dermatol 1953;68:334-335. 3. Asboe-Hansen G: Blister-spread induced by finger pressure, a diagnostic sign of pemphigus . J Invest Dermatol 1960;34:5. 4. Zone JJ, Provost TT: Bullous disease , in Moschella SL, Hurley HJ (eds): Dermatology . Philadelphia, WB Saunders Co, 1985, p 557. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Positive Nikolsky's and Bulla-Spread Signs in Acute Bullous Lichen Planus

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References (5)

Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1987.01660330029004
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— Nikolsky's and bulla-spread signs, originally described by Pyotr Vasilyevich Nikolsky1,2 and G. Asboe-Hansen3 have proved to be reliable diagnostic tests. Although once thought to be the sine qua non of pemphigus, these signs are also elicited in staphylococcal scalded skin syndrome, adult toxic epidermal necrolysis, and certain hereditary blistering diseases.4 We examined a patient with acute generalized lichen planus with bullae in whom these signs were demonstrated. We would like to share our experience through this communication. Report of a Case.— Intensely itchy, erythematous, violaceous lesions developed over the feet and legs of a 40-year-old woman. One month later, the lesions progressed over a span of two weeks to involve her whole body. Large blisters and vesicles appeared overlying the preexisting lesions on the sites of friction over her legs, knees, buttocks, and back, and painful ulcers developed. There was pain and discomfort when References 1. Arndt KA, Feingold DS: The sign of Pyotr Vasilyevich Nikolsky . N Engl J Med 1970;282:1154-1155.Crossref 2. Goodman H: Nikolsky's sign . Arch Dermatol 1953;68:334-335. 3. Asboe-Hansen G: Blister-spread induced by finger pressure, a diagnostic sign of pemphigus . J Invest Dermatol 1960;34:5. 4. Zone JJ, Provost TT: Bullous disease , in Moschella SL, Hurley HJ (eds): Dermatology . Philadelphia, WB Saunders Co, 1985, p 557.

Journal

Archives of DermatologyAmerican Medical Association

Published: Sep 1, 1987

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