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Positive Correlation of Corneal Thickness and Endothelial Cell Loss: Serial Measurements After Cataract Surgery

Positive Correlation of Corneal Thickness and Endothelial Cell Loss: Serial Measurements After... Abstract • A significant linear correlation was found between increase in corneal thickness (ACT) in the immediate postoperative period and percentage of cell loss one and six months after surgery in a prospective study on cataract surgery. Eyes were grouped according to ACT, and the groups were compared according to the percentage of cell loss. Eyes with ACT of 0.1 mm or more at five days lost significantly more cells at one and six months than eyes with ACT of less than 0.025 mm. Eyes were then regrouped according to the percentage of cell loss. Those with cell loss of 30% or more were found to have significantly greater ACT at 48 hours and five days than eyes with cell loss of less than 30%. The derived probability of cell loss of 30% or more increases the greater the value of ACT. For ACT of 100 μm or more at five days, the probability of high cell loss is 30%; this is nearly three times the likelihood that high cell loss had occurred when ACT is less than 100 μm. Our results suggest that ACT could be a useful clinical indicator of endothelial cell loss. References 1. Maurice DM: The cornea and sclera , in Davson H (ed): The Eye . Orlando, Fla, Academic Press Inc, 1984, vol 18, pp 75-89. 2. Waring GO, Bourne WM, Edelhauser HF, et al: The corneal endothelium: Normal and pathologic structure and function . Ophthalmology 1982;89:531-590.Crossref 3. Olsen T: Transient changes in specular appearance of the corneal endothelium and in corneal thickness during anterior uveitis . Acta Ophthalmol 1981;59:100-109.Crossref 4. Green K, Livingston V, Bowman K, et al: Chlorhexidine effects on corneal epithelium and endothelium . Arch Ophthalmol 1980;98:1273-1288.Crossref 5. Glasser DB, Matsuda M, Ellis JG, et al: Effects of intraocular irrigating solutions on the corneal endothelium after in vivo anterior chamber irrigation . Am J Ophthalmol 1985;99:321-328. 6. Mishima S: Clinical investigations on the corneal endothelium (38th Edward Jackson Memorial Lecture) . Am J Ophthalmol 1982;93:1-29. 7. Khodadoust AA, Green K: Physiological function of regenerating endothelium . Invest Ophthalmol Vis Sci 1976;15:96-101. 8. Oxford Cataract Treatment and Evaluation Team: Cataract surgery: Interim results and complications of a randomised controlled trial . Br J Ophthalmol 1986;70:402-414.Crossref 9. Mishima S, Hedbys BO: Measurement of corneal thickness with the Haag-Streit pachometer . Arch Ophthalmol 1968;80:710-713.Crossref 10. Azen SP, Burg KA, Smith RE: A comparison of three methods for the measurement of corneal thickness . Invest Ophthalmol Vis Sci 1979;18:535-538. 11. Cheng H, Jacobs PM, McPherson K, et al: Precision of cell density measurements and endothelial cell loss with age . Arch Ophthalmol 1985;103:1478-1481.Crossref 12. Oxford Cataract Treatment and Evaluation Team: Long-term corneal endothelial cell loss after cataract surgery . Arch Ophthalmol 1986;104:1170-1175.Crossref 13. Bayes RT: An essay towards solving a problem in the doctrines of chance . Biometrika 1958;45:293-315.Crossref 14. Hill AR: Decision making in ophthalmology , in Osborne N, Chader G (eds): Progress in Retinal Research . Elmsford, NY, Pergamon Press Inc, 1987, vol 6, pp 207-244. 15. Rao GN, Shaw EL, Arthur EJ, et al: Endothelial cell morphology and corneal deturgescence . Ann Ophthalmol 1979;11:885-889. 16. Olsen T: Corneal thickness and endothelial damage after intracapsular cataract extraction . Acta Ophthalmol 1980;58:424-433.Crossref 17. Olsen T, Eriksen JS: Corneal thickness and endothelial damage after intraocular lens implantation . Acta Ophthalmol 1980;58:773-786.Crossref 18. Kraff MC, Sanders DR, Lieberman HL: Specular microscopy in cataract and intraocular lens patients: A report of 564 cases . Arch Ophthalmol 1980;98:1782-1784.Crossref 19. Levy JH, Pisacano AM: Endothelial cell loss in four types of intraocular lens implant procedures . J Am Intraocul Implant Soc 1985;11:465-468.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Positive Correlation of Corneal Thickness and Endothelial Cell Loss: Serial Measurements After Cataract Surgery

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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1988.01060140066026
Publisher site
See Article on Publisher Site

Abstract

Abstract • A significant linear correlation was found between increase in corneal thickness (ACT) in the immediate postoperative period and percentage of cell loss one and six months after surgery in a prospective study on cataract surgery. Eyes were grouped according to ACT, and the groups were compared according to the percentage of cell loss. Eyes with ACT of 0.1 mm or more at five days lost significantly more cells at one and six months than eyes with ACT of less than 0.025 mm. Eyes were then regrouped according to the percentage of cell loss. Those with cell loss of 30% or more were found to have significantly greater ACT at 48 hours and five days than eyes with cell loss of less than 30%. The derived probability of cell loss of 30% or more increases the greater the value of ACT. For ACT of 100 μm or more at five days, the probability of high cell loss is 30%; this is nearly three times the likelihood that high cell loss had occurred when ACT is less than 100 μm. Our results suggest that ACT could be a useful clinical indicator of endothelial cell loss. References 1. Maurice DM: The cornea and sclera , in Davson H (ed): The Eye . Orlando, Fla, Academic Press Inc, 1984, vol 18, pp 75-89. 2. Waring GO, Bourne WM, Edelhauser HF, et al: The corneal endothelium: Normal and pathologic structure and function . Ophthalmology 1982;89:531-590.Crossref 3. Olsen T: Transient changes in specular appearance of the corneal endothelium and in corneal thickness during anterior uveitis . Acta Ophthalmol 1981;59:100-109.Crossref 4. Green K, Livingston V, Bowman K, et al: Chlorhexidine effects on corneal epithelium and endothelium . Arch Ophthalmol 1980;98:1273-1288.Crossref 5. Glasser DB, Matsuda M, Ellis JG, et al: Effects of intraocular irrigating solutions on the corneal endothelium after in vivo anterior chamber irrigation . Am J Ophthalmol 1985;99:321-328. 6. Mishima S: Clinical investigations on the corneal endothelium (38th Edward Jackson Memorial Lecture) . Am J Ophthalmol 1982;93:1-29. 7. Khodadoust AA, Green K: Physiological function of regenerating endothelium . Invest Ophthalmol Vis Sci 1976;15:96-101. 8. Oxford Cataract Treatment and Evaluation Team: Cataract surgery: Interim results and complications of a randomised controlled trial . Br J Ophthalmol 1986;70:402-414.Crossref 9. Mishima S, Hedbys BO: Measurement of corneal thickness with the Haag-Streit pachometer . Arch Ophthalmol 1968;80:710-713.Crossref 10. Azen SP, Burg KA, Smith RE: A comparison of three methods for the measurement of corneal thickness . Invest Ophthalmol Vis Sci 1979;18:535-538. 11. Cheng H, Jacobs PM, McPherson K, et al: Precision of cell density measurements and endothelial cell loss with age . Arch Ophthalmol 1985;103:1478-1481.Crossref 12. Oxford Cataract Treatment and Evaluation Team: Long-term corneal endothelial cell loss after cataract surgery . Arch Ophthalmol 1986;104:1170-1175.Crossref 13. Bayes RT: An essay towards solving a problem in the doctrines of chance . Biometrika 1958;45:293-315.Crossref 14. Hill AR: Decision making in ophthalmology , in Osborne N, Chader G (eds): Progress in Retinal Research . Elmsford, NY, Pergamon Press Inc, 1987, vol 6, pp 207-244. 15. Rao GN, Shaw EL, Arthur EJ, et al: Endothelial cell morphology and corneal deturgescence . Ann Ophthalmol 1979;11:885-889. 16. Olsen T: Corneal thickness and endothelial damage after intracapsular cataract extraction . Acta Ophthalmol 1980;58:424-433.Crossref 17. Olsen T, Eriksen JS: Corneal thickness and endothelial damage after intraocular lens implantation . Acta Ophthalmol 1980;58:773-786.Crossref 18. Kraff MC, Sanders DR, Lieberman HL: Specular microscopy in cataract and intraocular lens patients: A report of 564 cases . Arch Ophthalmol 1980;98:1782-1784.Crossref 19. Levy JH, Pisacano AM: Endothelial cell loss in four types of intraocular lens implant procedures . J Am Intraocul Implant Soc 1985;11:465-468.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Jul 1, 1988

References