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Population and Personalized Medicine in the Modern Era

Population and Personalized Medicine in the Modern Era Opinion Population and Personalized Medicine VIEWPOINT in the Modern Era Classic health care research has centered on studying sponse. In addition, some factors can determine how an Jessica L. Mega, MD, MPH a group of individuals and then extrapolating the find- individualmetabolizesamedication.Forexample,thean- TIMI Study Group, ings to the general population. In this context, evaluat- tiplateletagentclopidogrelisoneofmostcommonlypre- Division of ing the association between nonrandomized expo- scribed medications worldwide; however, interpatient Cardiovascular sures and clinical outcomes can yield interesting, variability in the response to clopidogrel is recognized. Medicine, Brigham and Women’s Hospital and hypothesis-generating correlations, but assembling Cytochrome P450 CYP enzymes play a role in the me- Harvard Medical evidence to suggest a causal relationship has focused on tabolism of clopidogrel, and carriers of particular genetic School, Boston, testing the relationship between randomized expo- variants in CYP2C19 have lower active clopidogrel me- Massachusetts. sures and clinical outcomes (Figure). tabolite levels, diminished platelet inhibition, and higher Clinical research has reached a pivotal moment, not rates of adverse cardiovascular events vs noncarriers. Marc S. Sabatine, MD, MPH onlywiththeexponentialexpansionoftoolsfordatacap- Thus, personalizing care, using both clinical and molecu- TIMI Study Group, tureaswellasdatasources,butalsowiththeopportunity lar factors, has merit in specific circumstances. Division of toreevaluatehowtointegratetheinformationtooptimize Fortunately, methods of data http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Population and Personalized Medicine in the Modern Era

Mega, Jessica L.; Sabatine, Marc S.; Antman, Elliott M.
JAMA , Volume 312 (19) – Nov 19, 2014
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References (8)

Publisher
American Medical Association
Copyright
Copyright 2014 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2014.15224
pmid
25399267
Publisher site
See Article on Publisher Site

Abstract

Opinion Population and Personalized Medicine VIEWPOINT in the Modern Era Classic health care research has centered on studying sponse. In addition, some factors can determine how an Jessica L. Mega, MD, MPH a group of individuals and then extrapolating the find- individualmetabolizesamedication.Forexample,thean- TIMI Study Group, ings to the general population. In this context, evaluat- tiplateletagentclopidogrelisoneofmostcommonlypre- Division of ing the association between nonrandomized expo- scribed medications worldwide; however, interpatient Cardiovascular sures and clinical outcomes can yield interesting, variability in the response to clopidogrel is recognized. Medicine, Brigham and Women’s Hospital and hypothesis-generating correlations, but assembling Cytochrome P450 CYP enzymes play a role in the me- Harvard Medical evidence to suggest a causal relationship has focused on tabolism of clopidogrel, and carriers of particular genetic School, Boston, testing the relationship between randomized expo- variants in CYP2C19 have lower active clopidogrel me- Massachusetts. sures and clinical outcomes (Figure). tabolite levels, diminished platelet inhibition, and higher Clinical research has reached a pivotal moment, not rates of adverse cardiovascular events vs noncarriers. Marc S. Sabatine, MD, MPH onlywiththeexponentialexpansionoftoolsfordatacap- Thus, personalizing care, using both clinical and molecu- TIMI Study Group, tureaswellasdatasources,butalsowiththeopportunity lar factors, has merit in specific circumstances. Division of toreevaluatehowtointegratetheinformationtooptimize Fortunately, methods of data

Journal

JAMA – American Medical Association

Published: Nov 19, 2014

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