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ARTICLE Poor Performance of Body Mass Index as a Marker for Hypercholesterolemia in Children and Adolescents Joyce M. Lee, MD, MPH; Achamyeleh Gebremariam, MS; Paula Card-Higginson, BA, ELS; Jennifer L. Shaw, DrPH, MPH, MAP; Joseph W. Thompson, MD, MPH; Matthew M. Davis, MD, MAPP Objective: To evaluate the test performance of specific Results: Receiver operating characteristic curves using body mass index (BMI) percentile cutoffs for detecting BMI percentiles to predict abnormal levels of TC and LDL children/adolescents with hypercholesterolemia. cholesterol had AUC values (0.60 for TC level and 0.63 for LDL cholesterol level) that were less than the thresh- Design: Cross-sectional analysis. old of acceptable discrimination (between 0.7-0.8). Body mass index percentiles provided better discrimination for Setting: National Health and Nutrition Examination Sur- detecting children with abnormal HDL cholesterol and vey 1999-2004. TG levels, with AUC values approaching levels of ac- ceptable discrimination (0.69 and 0.72, respectively), al- Participants: Population-based sample of children (aged though there are no specific guidelines regarding man- 3-18 years) with nonfasting total cholesterol (TC) and high- agement of children with these abnormalities. density lipoprotein (HDL) cholesterol levels and adoles- cents (aged 12-18 years) with fasting low-density lipopro- Conclusions: According to the American Academy of
JAMA Pediatrics – American Medical Association
Published: Aug 1, 2009
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