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Polyvascular Disease and Risk of Major Adverse Cardiovascular Events in Peripheral Artery Disease

Polyvascular Disease and Risk of Major Adverse Cardiovascular Events in Peripheral Artery Disease Key PointsQuestionDoes the presence of polyvascular disease affect the risk of ischemic events, both cardiac and limb, and bleeding in patients with peripheral artery disease? FindingsIn this secondary analysis of a randomized clinical trial of 13 885 patients with peripheral artery disease randomized to receive ticagrelor or clopidogrel compared with patients with isolated peripheral artery disease, those with concomitant peripheral artery disease and polyvascular disease had an increased risk of major adverse cardiac events and lower-extremity revascularization. Polyvascular disease was not associated with an increased risk of Thrombolysis in Myocardial Infarction major bleeding. MeaningThese data highlight the increased risk of coronary artery disease and cerebrovascular disease among patients with peripheral artery disease and the need to identify potent preventive antithrombotic therapies. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Network Open American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
eISSN
2574-3805
DOI
10.1001/jamanetworkopen.2018.5239
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionDoes the presence of polyvascular disease affect the risk of ischemic events, both cardiac and limb, and bleeding in patients with peripheral artery disease? FindingsIn this secondary analysis of a randomized clinical trial of 13 885 patients with peripheral artery disease randomized to receive ticagrelor or clopidogrel compared with patients with isolated peripheral artery disease, those with concomitant peripheral artery disease and polyvascular disease had an increased risk of major adverse cardiac events and lower-extremity revascularization. Polyvascular disease was not associated with an increased risk of Thrombolysis in Myocardial Infarction major bleeding. MeaningThese data highlight the increased risk of coronary artery disease and cerebrovascular disease among patients with peripheral artery disease and the need to identify potent preventive antithrombotic therapies.

Journal

JAMA Network OpenAmerican Medical Association

Published: Nov 30, 2018

References