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Polymorphic Light Eruption Reassessed

Polymorphic Light Eruption Reassessed EDITORIAL OLYMORPHIC LIGHT ERUPTION (PLE) IS POSSI- sion, was seen in neutrophils rather than in keratino- bly the most common chronic skin disorder cytes. Fewer neutrophils were apparent in the UV- in people living in temperate climes. Self- irradiated skin of PLE patients than in healthy subjects, report questionnaire surveys suggest a preva- and therefore it seems that failure of a normal degree of P lence of about 15% in the northern hemi- neutrophilic infiltration might explain the reduced cy- sphere. It is therefore appropriate that the current research tokine induction and consequently the lesser degree of programs of some specialist centers include a reassess- photoimmunosuppression in PLE. ment of this disease, including its cause and diagnosis. Further exploration is required of this fascinating In this issue of the ARCHIVES, 2 articles address dif- area. As discussed by the authors, it would be helpful if ferent aspects of PLE. A team of Dutch investigators have cytokine messenger RNA and protein could be quanti- examined the mechanism of the apparent underlying im- fied to fully assess the significance of the findings by us- mune defect, whereas a British group reassessed the meth- ing reverse transcriptase polymerase chain reaction and odology http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

Polymorphic Light Eruption Reassessed

JAMA Dermatology , Volume 140 (3) – Mar 1, 2004

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Publisher
American Medical Association
Copyright
Copyright 2004 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/archderm.140.3.351
pmid
15023779
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL OLYMORPHIC LIGHT ERUPTION (PLE) IS POSSI- sion, was seen in neutrophils rather than in keratino- bly the most common chronic skin disorder cytes. Fewer neutrophils were apparent in the UV- in people living in temperate climes. Self- irradiated skin of PLE patients than in healthy subjects, report questionnaire surveys suggest a preva- and therefore it seems that failure of a normal degree of P lence of about 15% in the northern hemi- neutrophilic infiltration might explain the reduced cy- sphere. It is therefore appropriate that the current research tokine induction and consequently the lesser degree of programs of some specialist centers include a reassess- photoimmunosuppression in PLE. ment of this disease, including its cause and diagnosis. Further exploration is required of this fascinating In this issue of the ARCHIVES, 2 articles address dif- area. As discussed by the authors, it would be helpful if ferent aspects of PLE. A team of Dutch investigators have cytokine messenger RNA and protein could be quanti- examined the mechanism of the apparent underlying im- fied to fully assess the significance of the findings by us- mune defect, whereas a British group reassessed the meth- ing reverse transcriptase polymerase chain reaction and odology

Journal

JAMA DermatologyAmerican Medical Association

Published: Mar 1, 2004

References