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Polygenic Risk Scores Derived From Varying Definitions of Depression and Risk of Depression

Polygenic Risk Scores Derived From Varying Definitions of Depression and Risk of Depression Key PointsQuestionTo what extent does the depth of phenotyping matter in genetic studies of depression? FindingsIn this case-control polygenic risk score analysis including 12 106 individuals with major depressive disorder, the major factor in estimating risk was sample size of the discovery genome-wide association studies. Polygenic risk scores derived from studies assessing diagnostic criteria for major depressive disorder had associations with higher odds ratios with somatic symptoms and comorbidities of major depressive disorder. MeaningResults of this study suggest that to generate potential better genetic estimations of risk for severe depression, larger genome-wide association study sample sizes, regardless of the depth of phenotyping, should be prioritized. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2021 American Medical Association. All Rights Reserved.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/jamapsychiatry.2021.1988
Publisher site
See Article on Publisher Site

Abstract

Key PointsQuestionTo what extent does the depth of phenotyping matter in genetic studies of depression? FindingsIn this case-control polygenic risk score analysis including 12 106 individuals with major depressive disorder, the major factor in estimating risk was sample size of the discovery genome-wide association studies. Polygenic risk scores derived from studies assessing diagnostic criteria for major depressive disorder had associations with higher odds ratios with somatic symptoms and comorbidities of major depressive disorder. MeaningResults of this study suggest that to generate potential better genetic estimations of risk for severe depression, larger genome-wide association study sample sizes, regardless of the depth of phenotyping, should be prioritized.

Journal

JAMA PsychiatryAmerican Medical Association

Published: Oct 11, 2021

References