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- Publisher
- American Medical Association
- Copyright
- Copyright 2021 American Medical Association. All Rights Reserved.
- ISSN
- 2168-622X
- eISSN
- 2168-6238
- DOI
- 10.1001/jamapsychiatry.2021.1988
- Publisher site
- See Article on Publisher Site
Abstract
Key PointsQuestionTo what extent does the depth of phenotyping matter in genetic studies of depression? FindingsIn this case-control polygenic risk score analysis including 12 106 individuals with major depressive disorder, the major factor in estimating risk was sample size of the discovery genome-wide association studies. Polygenic risk scores derived from studies assessing diagnostic criteria for major depressive disorder had associations with higher odds ratios with somatic symptoms and comorbidities of major depressive disorder. MeaningResults of this study suggest that to generate potential better genetic estimations of risk for severe depression, larger genome-wide association study sample sizes, regardless of the depth of phenotyping, should be prioritized.
Journal
JAMA Psychiatry – American Medical Association
Published: Oct 11, 2021