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POLYCYTHEMIA VERA TERMINATING IN ACUTE LEUKEMIA: Report of a Case and Review of Literature

POLYCYTHEMIA VERA TERMINATING IN ACUTE LEUKEMIA: Report of a Case and Review of Literature Abstract THE TERMINATION of polycythemia vera in acute leukemia is an infrequent occurrence. Because of the scarcity of such reports opportunity is taken to report one such case and to review others noted in the previous literature. T. K., a 65-year-old white woman, was admitted to the Albert Einstein Medical Center, Southern Division, on March 20, 1953, because of weakness and pallor. She was known to have polycythemia vera since June, 1941, and was treated with venesections, x-rays, and P32 (Table). Physical examination revealed an elderly woman in acute distress. B. P., 130/70; pulse, 100; respiration rate, 20; temperature, 102 F. Marked pallor, purpura, and splenomegaly were noted. There was no icterus, adenopathy, hepatomegaly, or glossitis. Blood studies showed RBC, 3,340,000; Hb., 9.7 gm.; reticulocytes, 0.9%; platelets, 140,000; WBC, 7400, with 1% segmented cells, 5% lymphocytes, 3% myelocytes, 3% promyelocytes, and 88% blast forms. A sternal marrow biopsy revealed a References 1. References 1-5 2. Dameshek, W., cited by Wasserman.3 3. Dameshek, W., cited by Wasserman. 4. Lawrence, J. H.; Berlin, N. I., and Huff, R. L.: The Nature and Treatment of Polycythemia Vera: Studies on 263 Patients , Medicine 32:323-388, 1953.Crossref 5. Stroebel, C. F.; Hall, B. E., and Pease, G. L.: Evaluation of Radiophosphorus Therapy in Primary Polycythemia , J. A. M. A. 146:1301-1307, 1951.Crossref 6. Wasserman, L. R.: Polycythemia Vera: Its Course and Treatment; Relation to Myeloid Metaplasia and Leukemia , Bull. New York Acad. Med. 30:343-375, 1954. 7. Wiseman, B. K.; Rohn, R. H.; Bouroncle, B. A., and Myers, W. G.: The Treatment of Polycythemia Vera with Radioactive Phosphorus , Ann. Int. Med. 34:311-330, 1951.Crossref 8. Schwartz, S. O., and Ehrlich, L.: The Relationship of Polycythemia Vera to Leukemia , Acta haemat. 4:129-147, 1950.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Internal Medicine American Medical Association

POLYCYTHEMIA VERA TERMINATING IN ACUTE LEUKEMIA: Report of a Case and Review of Literature

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Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0888-2479
DOI
10.1001/archinte.1955.00250150139015
Publisher site
See Article on Publisher Site

Abstract

Abstract THE TERMINATION of polycythemia vera in acute leukemia is an infrequent occurrence. Because of the scarcity of such reports opportunity is taken to report one such case and to review others noted in the previous literature. T. K., a 65-year-old white woman, was admitted to the Albert Einstein Medical Center, Southern Division, on March 20, 1953, because of weakness and pallor. She was known to have polycythemia vera since June, 1941, and was treated with venesections, x-rays, and P32 (Table). Physical examination revealed an elderly woman in acute distress. B. P., 130/70; pulse, 100; respiration rate, 20; temperature, 102 F. Marked pallor, purpura, and splenomegaly were noted. There was no icterus, adenopathy, hepatomegaly, or glossitis. Blood studies showed RBC, 3,340,000; Hb., 9.7 gm.; reticulocytes, 0.9%; platelets, 140,000; WBC, 7400, with 1% segmented cells, 5% lymphocytes, 3% myelocytes, 3% promyelocytes, and 88% blast forms. A sternal marrow biopsy revealed a References 1. References 1-5 2. Dameshek, W., cited by Wasserman.3 3. Dameshek, W., cited by Wasserman. 4. Lawrence, J. H.; Berlin, N. I., and Huff, R. L.: The Nature and Treatment of Polycythemia Vera: Studies on 263 Patients , Medicine 32:323-388, 1953.Crossref 5. Stroebel, C. F.; Hall, B. E., and Pease, G. L.: Evaluation of Radiophosphorus Therapy in Primary Polycythemia , J. A. M. A. 146:1301-1307, 1951.Crossref 6. Wasserman, L. R.: Polycythemia Vera: Its Course and Treatment; Relation to Myeloid Metaplasia and Leukemia , Bull. New York Acad. Med. 30:343-375, 1954. 7. Wiseman, B. K.; Rohn, R. H.; Bouroncle, B. A., and Myers, W. G.: The Treatment of Polycythemia Vera with Radioactive Phosphorus , Ann. Int. Med. 34:311-330, 1951.Crossref 8. Schwartz, S. O., and Ehrlich, L.: The Relationship of Polycythemia Vera to Leukemia , Acta haemat. 4:129-147, 1950.Crossref

Journal

A.M.A. Archives of Internal MedicineAmerican Medical Association

Published: Oct 1, 1955

References