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Poliovirus Vaccines: Past, Present, and Future

Poliovirus Vaccines: Past, Present, and Future COMMENTARY N IMPORTANT PEDI- system; because poliovirus circu- confers “herd immunity” on a popu- atric advance of the lates as a plasma viremia, it can be lation that is only partly vacci- 1950s was the intro- neutralized by a low titer of circu- nated. However, on human pas- duction of inacti- lating antibodies that is readily in- sage, OPV can revert to a virulent A vated poliovirus vac- duced by IPV. Wild poliovirus can phenotype, a potentially danger- cine (IPV), also known as the Salk be grouped into 3 serotypes requir- ous property. vaccine. Inactivated poliovirus vac- ing a trivalent immunogen but, luck- cine and its counterpart, oral polio- ily, the virus cannot escape via mu- PREVENTION OF virus vaccine (OPV), also known as tations at the neutralizing epitopes. PARALYTIC POLIOMYELITIS the Sabin vaccine, have saved hun- Hence, the original formulation of dreds of thousands of children and IPV can protect against all wild po- During the early 1950s, between adults from contracting paralytic po- lioviruses that circulate in nature. 10 000 and 20 000 annual cases of liomyelitis, a major scourge of the This property contrasts with that of paralytic poliomyelitis were re- mid-20th century. The celebra- the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Pediatrics American Medical Association

Poliovirus Vaccines: Past, Present, and Future

JAMA Pediatrics , Volume 165 (6) – Jun 1, 2011

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Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6203
eISSN
2168-6211
DOI
10.1001/archpediatrics.2011.77
pmid
21646582
Publisher site
See Article on Publisher Site

Abstract

COMMENTARY N IMPORTANT PEDI- system; because poliovirus circu- confers “herd immunity” on a popu- atric advance of the lates as a plasma viremia, it can be lation that is only partly vacci- 1950s was the intro- neutralized by a low titer of circu- nated. However, on human pas- duction of inacti- lating antibodies that is readily in- sage, OPV can revert to a virulent A vated poliovirus vac- duced by IPV. Wild poliovirus can phenotype, a potentially danger- cine (IPV), also known as the Salk be grouped into 3 serotypes requir- ous property. vaccine. Inactivated poliovirus vac- ing a trivalent immunogen but, luck- cine and its counterpart, oral polio- ily, the virus cannot escape via mu- PREVENTION OF virus vaccine (OPV), also known as tations at the neutralizing epitopes. PARALYTIC POLIOMYELITIS the Sabin vaccine, have saved hun- Hence, the original formulation of dreds of thousands of children and IPV can protect against all wild po- During the early 1950s, between adults from contracting paralytic po- lioviruses that circulate in nature. 10 000 and 20 000 annual cases of liomyelitis, a major scourge of the This property contrasts with that of paralytic poliomyelitis were re- mid-20th century. The celebra- the

Journal

JAMA PediatricsAmerican Medical Association

Published: Jun 1, 2011

References

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