COMMENTARY N IMPORTANT PEDI- system; because poliovirus circu- confers “herd immunity” on a popu- atric advance of the lates as a plasma viremia, it can be lation that is only partly vacci- 1950s was the intro- neutralized by a low titer of circu- nated. However, on human pas- duction of inacti- lating antibodies that is readily in- sage, OPV can revert to a virulent A vated poliovirus vac- duced by IPV. Wild poliovirus can phenotype, a potentially danger- cine (IPV), also known as the Salk be grouped into 3 serotypes requir- ous property. vaccine. Inactivated poliovirus vac- ing a trivalent immunogen but, luck- cine and its counterpart, oral polio- ily, the virus cannot escape via mu- PREVENTION OF virus vaccine (OPV), also known as tations at the neutralizing epitopes. PARALYTIC POLIOMYELITIS the Sabin vaccine, have saved hun- Hence, the original formulation of dreds of thousands of children and IPV can protect against all wild po- During the early 1950s, between adults from contracting paralytic po- lioviruses that circulate in nature. 10 000 and 20 000 annual cases of liomyelitis, a major scourge of the This property contrasts with that of paralytic poliomyelitis were re- mid-20th century. The celebra- the
JAMA Pediatrics – American Medical Association
Published: Jun 1, 2011
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