Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

POISONING DUE TO OIL OF CHENOPODIUM

POISONING DUE TO OIL OF CHENOPODIUM Oil of chenopodrem, or American wormseed oil, a part of the physician's armamentarium for the treatment of intestinal parasites, can give rise to alarming toxic symptoms and death, even when given in therapeutic doses. Wormseed oil, extracted by steam distillation, is the volatile oil of the fruit of Chenopodium ambrosioides, var. anthelminticum. This oil is a pale yellow liquid with an unpleasant odor and a bitter, burning taste. The chemical constituents are ascaridole, p-cymene, d-camphor, 1-limonene and saponins. Its anthelmintic property is ascribed to the ascaridole content and the toxicity to either the active ingredient or cymene. Newer therapeutic agents have largely replaced oil of chenopodium, but it still finds use in the treatment of hookworm, roundworm and pinworm infections. It acts by paralyzing the worm rather than by causing its immediate death. The mode of action explains the rationale of following administration of the drug by purgation. Toxic reactions http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

POISONING DUE TO OIL OF CHENOPODIUM

JAMA , Volume 132 (6) – Oct 12, 1946

Loading next page...
 
/lp/american-medical-association/poisoning-due-to-oil-of-chenopodium-c1rLr1CB5T

References (0)

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
American Medical Association
Copyright
Copyright © 1946 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1946.02870410018006a
Publisher site
See Article on Publisher Site

Abstract

Oil of chenopodrem, or American wormseed oil, a part of the physician's armamentarium for the treatment of intestinal parasites, can give rise to alarming toxic symptoms and death, even when given in therapeutic doses. Wormseed oil, extracted by steam distillation, is the volatile oil of the fruit of Chenopodium ambrosioides, var. anthelminticum. This oil is a pale yellow liquid with an unpleasant odor and a bitter, burning taste. The chemical constituents are ascaridole, p-cymene, d-camphor, 1-limonene and saponins. Its anthelmintic property is ascribed to the ascaridole content and the toxicity to either the active ingredient or cymene. Newer therapeutic agents have largely replaced oil of chenopodium, but it still finds use in the treatment of hookworm, roundworm and pinworm infections. It acts by paralyzing the worm rather than by causing its immediate death. The mode of action explains the rationale of following administration of the drug by purgation. Toxic reactions

Journal

JAMAAmerican Medical Association

Published: Oct 12, 1946

There are no references for this article.