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Pneumococcal Septicemia in Sickle Cell Disease

Pneumococcal Septicemia in Sickle Cell Disease Abstract Sir.—In their article in the May issue of the Archives, Buchanan and Smith1 raise the flag again for those of us who treat patients with sickle cell disease; pneumococcal septicemia is still with us despite all of the work on the vaccine and prophylaxis with penicillin. Buchanan and Smith point out the failure of the vaccine when given before the second birthday. It is disturbing that only two of the pneumococcal serotypes are contained in the commercially available vaccine, which means that the six other episodes might not have been prevented regardless of the age at which the vaccine was given. Buchanan and Smith also point out the problem of compliance with penicillin prophylaxis. If compliance is a problem in their well-organized sickle cell clinic in a developed country, you can imagine the problem for those who work in less developed countries with limited resources, low socioeconomic status, References 1. Buchanan GR, Smith SJ: Pneumococcal septicemia despite pneumococcal vaccine and prescription of penicillin prophylaxis in children with sickle cell anemia . AJDC 1986;140:428-432. 2. Broome CV, Facklam RR: Epidemiology of clinically significant isolates of Streptococcus pneumoniae in the United States . Rev Infect Dis 1980;3:277-280.Crossref 3. Greenwood BM, Hassan-King M, MacFarlane JT, et al: Pneumococcal serotypes in West Africa . Lancet 1980;1:360.Crossref 4. Mahgoub ES, Hussein SS: Streptococcus pneumoniae serotypes and their minimal inhibitory concentration to penicillin, Riyadh . Saudi Med J 1986;7:149-154. 5. Mallouh AA, Salamah MM: Pattern of bacterial infections in homozygous sickle cell disease . AJDC 1985;139:820-822. 6. Mallouh AA, Burke GM, Salamah MM, et al: Splenic function in Saudi children with sickle cell disease . Ann Trop Paediatr 1984;4:87-91. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Pneumococcal Septicemia in Sickle Cell Disease

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1986.02140250018007
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—In their article in the May issue of the Archives, Buchanan and Smith1 raise the flag again for those of us who treat patients with sickle cell disease; pneumococcal septicemia is still with us despite all of the work on the vaccine and prophylaxis with penicillin. Buchanan and Smith point out the failure of the vaccine when given before the second birthday. It is disturbing that only two of the pneumococcal serotypes are contained in the commercially available vaccine, which means that the six other episodes might not have been prevented regardless of the age at which the vaccine was given. Buchanan and Smith also point out the problem of compliance with penicillin prophylaxis. If compliance is a problem in their well-organized sickle cell clinic in a developed country, you can imagine the problem for those who work in less developed countries with limited resources, low socioeconomic status, References 1. Buchanan GR, Smith SJ: Pneumococcal septicemia despite pneumococcal vaccine and prescription of penicillin prophylaxis in children with sickle cell anemia . AJDC 1986;140:428-432. 2. Broome CV, Facklam RR: Epidemiology of clinically significant isolates of Streptococcus pneumoniae in the United States . Rev Infect Dis 1980;3:277-280.Crossref 3. Greenwood BM, Hassan-King M, MacFarlane JT, et al: Pneumococcal serotypes in West Africa . Lancet 1980;1:360.Crossref 4. Mahgoub ES, Hussein SS: Streptococcus pneumoniae serotypes and their minimal inhibitory concentration to penicillin, Riyadh . Saudi Med J 1986;7:149-154. 5. Mallouh AA, Salamah MM: Pattern of bacterial infections in homozygous sickle cell disease . AJDC 1985;139:820-822. 6. Mallouh AA, Burke GM, Salamah MM, et al: Splenic function in Saudi children with sickle cell disease . Ann Trop Paediatr 1984;4:87-91.

Journal

American Journal of Diseases of Children – American Medical Association

Published: Nov 1, 1986

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