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Pleomorphic Carcinoma of the Larynx

Pleomorphic Carcinoma of the Larynx Abstract THIS unusual and rare lesion has been called squamous cell carcinoma with sarcoma-like stroma, carcinosarcoma, pseudosarcoma, etc. It has interesting clinical, morphologic and histopathologic facets. The primary lesion is a squamous cell or epidermoid carcinoma, but this is often overshadowed or completely missed because of a stroma which suggests anything from high grade spindle cell carcinoma to a variety of sarcoma types, or just a fibroblastic proliferation associated with a chronic inflammatory cell reaction. The source of the spindle cell component, stromal or epithelial, is argued. Present consensus is that the source is epithelial and that the various tumor cell forms encountered in the stroma all stem from the squamous epithelium: a truly pleomorphic phenomenon. Our cases below demonstrate this apparent transformation from squamous to spindle cell forms. Carcinosarcoma and collision tumor warrant differential discussion. The term pseudosarcoma deserves mention. Paradoxically, the histopathology implies a high degree of malignancy, yet References 1. Baker, D.C., Jr.: Pseudosarcoma of the Pharynx and Larynx , Ann Oto 68:471-477 ( (June) ) 1959. 2. Lane, N.: Pseudosarcoma (Polypoid Sarcoma-Like Masses) Associated With Squamous-Cell Carcinoma of the Mouth, Fauces, and Larynx , Cancer 10:19-41, 1957.Crossref 3. Ash, Col. J.E., and Raum, M.: An Atlas of Otolaryngic Pathology , Armed Forces Institute of Pathology, p 354, 1949. 4. Sherwin, R.P.; Strong, M.S.; and Vaughn, C.W., Jr.: Polypoid and Junctional Squamous Cell Carcinoma of the Tongue and Larynx With Spindle Cell Carcinoma (Pseudosarcoma) , Cancer 16:51-60, 1963.Crossref 5. Appelman, H.D., and Oberman, H.A.: Squamous Cell Carcinoma of the Larynx With Sarcoma-Like Stroma , Amer J Clin Path 44:135 ( (Aug) ) 1965. 6. Lillie, J.C.: Vocal Cord Surgery , Surg Clin N Amer 43:1090, 1963. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1968 American Medical Association. All Rights Reserved.
ISSN
0003-9977
DOI
10.1001/archotol.1968.00760060391010
Publisher site
See Article on Publisher Site

Abstract

Abstract THIS unusual and rare lesion has been called squamous cell carcinoma with sarcoma-like stroma, carcinosarcoma, pseudosarcoma, etc. It has interesting clinical, morphologic and histopathologic facets. The primary lesion is a squamous cell or epidermoid carcinoma, but this is often overshadowed or completely missed because of a stroma which suggests anything from high grade spindle cell carcinoma to a variety of sarcoma types, or just a fibroblastic proliferation associated with a chronic inflammatory cell reaction. The source of the spindle cell component, stromal or epithelial, is argued. Present consensus is that the source is epithelial and that the various tumor cell forms encountered in the stroma all stem from the squamous epithelium: a truly pleomorphic phenomenon. Our cases below demonstrate this apparent transformation from squamous to spindle cell forms. Carcinosarcoma and collision tumor warrant differential discussion. The term pseudosarcoma deserves mention. Paradoxically, the histopathology implies a high degree of malignancy, yet References 1. Baker, D.C., Jr.: Pseudosarcoma of the Pharynx and Larynx , Ann Oto 68:471-477 ( (June) ) 1959. 2. Lane, N.: Pseudosarcoma (Polypoid Sarcoma-Like Masses) Associated With Squamous-Cell Carcinoma of the Mouth, Fauces, and Larynx , Cancer 10:19-41, 1957.Crossref 3. Ash, Col. J.E., and Raum, M.: An Atlas of Otolaryngic Pathology , Armed Forces Institute of Pathology, p 354, 1949. 4. Sherwin, R.P.; Strong, M.S.; and Vaughn, C.W., Jr.: Polypoid and Junctional Squamous Cell Carcinoma of the Tongue and Larynx With Spindle Cell Carcinoma (Pseudosarcoma) , Cancer 16:51-60, 1963.Crossref 5. Appelman, H.D., and Oberman, H.A.: Squamous Cell Carcinoma of the Larynx With Sarcoma-Like Stroma , Amer J Clin Path 44:135 ( (Aug) ) 1965. 6. Lillie, J.C.: Vocal Cord Surgery , Surg Clin N Amer 43:1090, 1963.

Journal

Archives of OtolaryngologyAmerican Medical Association

Published: Apr 1, 1968

References

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