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Platelet Aggregation Test in the Study of Hepatitis

Platelet Aggregation Test in the Study of Hepatitis Abstract The platelet aggregation test (PLA) can be used as an indicator of Australia antigen or antibody in the serum.1,2 The reaction of Au antigen-Au antibody complexes with human platelets changes the pattern of sedimentation of platelets on microplates.2 This method has also been used to detect other antibodies and antigens.3 When PLA was used to study hepatitis sera, it was soon found that many of these sera reacted directly with platelets without any added antibody or antigen. Earlier studies show that this can be a sign of the presence of immune complexes in the blood.4 The possibility of immune complexes in severe hepatitis cases has recently been under special consideration.5 This paper presents the results of 93 cases of different forms of hepatitis, 49 other diseases, and 99 blood donors. Special consideration is given to the "direct" reactivity of sera. The detection of the References 1. Melartin L, Myllylä G, Penttinen K: Detection of Au (1) antigen by immunodiffusion and platelet aggregation tests . Vox Sang 19:239-245, 1970.Crossref 2. Penttinen K, Myllylä G: Viral hepatitis and tests for the Australia (hepatitisassociated) antigen and antibody . Bull Org Mond Sante 42:980-982, 1970. 3. Penttinen K, Vaheri A, Myllylä G: Soluble antigen-antibody complexes and platelet aggregation . Acta Path Microb Scand 77:309-317, 1969.Crossref 4. Myllylä G, Vaheri A, Penttinen K: Detection and characterization of immune complexes by the platelet aggregation test: II. Circulating complexes . Clin Exp Immunol 8:399-408, 1971. 5. Almeida JD, Waterson AP: Immune complexes in hepatitis . Lancet 2:983-986, 1969.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Platelet Aggregation Test in the Study of Hepatitis

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Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1972.02110100150058
Publisher site
See Article on Publisher Site

Abstract

Abstract The platelet aggregation test (PLA) can be used as an indicator of Australia antigen or antibody in the serum.1,2 The reaction of Au antigen-Au antibody complexes with human platelets changes the pattern of sedimentation of platelets on microplates.2 This method has also been used to detect other antibodies and antigens.3 When PLA was used to study hepatitis sera, it was soon found that many of these sera reacted directly with platelets without any added antibody or antigen. Earlier studies show that this can be a sign of the presence of immune complexes in the blood.4 The possibility of immune complexes in severe hepatitis cases has recently been under special consideration.5 This paper presents the results of 93 cases of different forms of hepatitis, 49 other diseases, and 99 blood donors. Special consideration is given to the "direct" reactivity of sera. The detection of the References 1. Melartin L, Myllylä G, Penttinen K: Detection of Au (1) antigen by immunodiffusion and platelet aggregation tests . Vox Sang 19:239-245, 1970.Crossref 2. Penttinen K, Myllylä G: Viral hepatitis and tests for the Australia (hepatitisassociated) antigen and antibody . Bull Org Mond Sante 42:980-982, 1970. 3. Penttinen K, Vaheri A, Myllylä G: Soluble antigen-antibody complexes and platelet aggregation . Acta Path Microb Scand 77:309-317, 1969.Crossref 4. Myllylä G, Vaheri A, Penttinen K: Detection and characterization of immune complexes by the platelet aggregation test: II. Circulating complexes . Clin Exp Immunol 8:399-408, 1971. 5. Almeida JD, Waterson AP: Immune complexes in hepatitis . Lancet 2:983-986, 1969.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Apr 1, 1972

References