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Plasma Renin Activity During Levodopa Therapy

Plasma Renin Activity During Levodopa Therapy Plasma renin activity (PRA) was studied in six patients with Parkinson disease under identical conditions of diet and posture before and after seven days of levodopa administration. Significant differences were not found at seven days, nor when the measurement was repeated under similar conditions of sodium excretion after six months of therapy. The PRA responded appropriately to posture before and after therapy. After six months of therapy, sodium restriction resulted in an appropriate response of PRA and aldosterone secretion. A small but significant fall in blood pressure took place seven days after the initiation of levodopa therapy, at which time PRA had not changed significantly. After six months of therapy, blood pressure had returned to control levels. This study suggests that the renin-aldosterone system is not significantly altered by levodopa therapy of Parkinson disease. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Plasma Renin Activity During Levodopa Therapy

Sullivan, Jay M.; Nakano, Kenneth K.; Tyler, H. Richard
JAMA , Volume 224 (13) – Jun 25, 1973
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References (20)

Publisher
American Medical Association
Copyright
Copyright © 1973 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1973.03220270022007
Publisher site
See Article on Publisher Site

Abstract

Plasma renin activity (PRA) was studied in six patients with Parkinson disease under identical conditions of diet and posture before and after seven days of levodopa administration. Significant differences were not found at seven days, nor when the measurement was repeated under similar conditions of sodium excretion after six months of therapy. The PRA responded appropriately to posture before and after therapy. After six months of therapy, sodium restriction resulted in an appropriate response of PRA and aldosterone secretion. A small but significant fall in blood pressure took place seven days after the initiation of levodopa therapy, at which time PRA had not changed significantly. After six months of therapy, blood pressure had returned to control levels. This study suggests that the renin-aldosterone system is not significantly altered by levodopa therapy of Parkinson disease.

Journal

JAMA – American Medical Association

Published: Jun 25, 1973

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