Abstract Increased numbers of plasma cells are often found in the bone marrow and peripheral blood of patients with multiple myeloma and, occasionally, in those with granulomatous diseases and other chronic disorders. Rarely, however, have plasma cells been reported in the urine. We report a case of multiple myeloma in which numerous plasma cells were found in the urine. PATIENT SUMMARY A 65-year-old woman had been in good health until April 1973, when she noted the onset of pain in the lower part of the back. During the next two months, she experienced an 8.1 kg (18 lb) weight loss. She was treated for a "kidney infection" with antibiotics in May. In late June, the diagnosis of multiple myeloma was made on the basis of a monoclonal spike on urine electrophoresis and multiple osteolytic defects on skeletal x-ray films. Bone marrow examination at that time showed 5% plasma cells. A course References 1. Abramson N, von Kapff G, Ginsburg AD: The phagocytic plasma cells. N Engl J Med 283:248-250, 1970.Crossref 2. Butterworth CE, Frommeyer WB, Riser WH: Erythrophagocytosis in a case of plasma cell leukemia. Blood 8:519-523, 1953. 3. Reisberg MA, Rossen RD, Butler WT: A method for preparing specific fluorescein-conjugated antibody reagents using bentonite immunoabsorbent reagents. J Immunol 105:1151-1161, 1970. 4. Martinez-Maldonado M, Yium J, Suki WN, et al: Renal complications in multiple myeloma: Pathophysiology and some aspects of clinical management. J Chronic Dis 24:221-237, 1971.Crossref 5. Khan AB, et al: Myelomatosis with "myeloma cells" in the urine. Indian J Med 45:553-554, 1965. 6. Kunwar KB, Kumar S: Multiple myeloma with myeloma cells in the urine. Indian J Med 20:641-643, 1966. 7. Prowse CM, Blecher TE: Exfoliated "myeloma cells" in the urine in a case of multiple myelomatosis. J Clin Pathol 15:136-140, 1962.Crossref 8. Rees ED, Waugh WH: Factors in the renal failure of multiple myeloma. Arch Intern Med 116:400-405, 1965.Crossref 9. Heptinstall RH: Amyloidosis, multiple myeloma, and Waldenstrom's macroglobulinemia , in Pathology of the Kidney . Boston, Little, Brown & Co, 1966, pp 585-594. 10. Fisher ER, Perez-Stable E, Sawadzki ZA: Ultrastructural renal changes in multiple myeloma with comments relative to the mechanism of proteinuria. Lab Invest 13:1561-1574, 1964. 11. Newns GR, Edwards JL: A case of plasma cell myelomatosis with a large renal metastasis and widespread renal tubular obstruction. J Pathol Bacteriol 56:259-262, 1944.Crossref 12. Davides KC, et al: Plasma cell granuloma of the renal pelvis. J Urol 107:938-939, 1972. 13. O'Flynn WR, Sandrey JG: Nonspecific granulomata of the ureter and bladder. Br J Urol 35:267-276, 1963.Crossref 14. Pringle JP, Graham RC, Bemier GM: Detection of myeloma cells in urine sediment. Blood 43:137-143, 1974.
Archives of Internal Medicine – American Medical Association
Published: Sep 1, 1975