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PICK'S DISEASE: A CLINICOPATHOLOGIC CONTRIBUTION

PICK'S DISEASE: A CLINICOPATHOLOGIC CONTRIBUTION Abstract In 1892 Arnold Pick1 published his first observation on atrophy of the brain with focal lesions, which he interpreted as atypical senile dementia. In analyzing the syndrome he was mainly concerned in correlating the clinical picture with the localization of the lesions. The great significance of Pick's contribution was not recognized until later studies proved that the symptom complex originally outlined was in reality a disease entity. The disease is rare, about fifty cases having been reported in the literature. In spite of recent studies clinical diagnosis remains difficult, but knowledge of the pathologic features has been considerably enlarged. Four new cases are reported here. REPORT OF CASES Case 1. —Enda N., aged 47, married, the mother of six children, was admitted to the hospital on May 13, 1931. There were no known hereditary trends. She had had a colloid goiter and "choking spells" for the past several years. References 1. Pick, A.: Beiträge zur Pathologie und pathologischen Anatomie des Centralnervensystems, mit Bemerkungen zur normalen Anatomie desselben , Berlin, S. Karger, 1898. 2. von Braunmühl, A., in von Bumke, O.: Handbuch des Geisteskrankheiten , Berlin, Julius Springer, 1931, vol. II, pt. 7, p. 673. 3. Liepmann: Neurol. Centralbl. 19:328, 1900. 4. Lemke, R.: Arch. f. Psychiat. 101:623, 1934.Crossref 5. van Husen, T.: Allg. Ztschr. f Psychiat. 101: 381, 1934. 6. Schmitz, H. A., and Meyer, A.: Arch f. Psychiat. 99: 747, 1933.Crossref 7. von Braunmühl, A., and Leonhard, K.: Ztschr. f. d. ges. Neurol. u. Psychiat. 150: 209, 1934.Crossref 8. Schneider, C.: Monatschr. f. Psychiat. u. Neurol. 65: 230, 1927.Crossref 9. Stertz, G.: Ztschr. f. d. ges. Neurol. u. Psychiat. 101: 729, 1926.Crossref 10. Rosenfeld, M.: Ztschr. f. Psychol. u. Neurol. 14:115, 1909. 11. Heilbronner: Arch. f Psychiat. 33:366, 1900.Crossref 12. Altmann, E.: Ztschr. f. d. ges. Neurol. u. Psychiat. 83:610, 1923.Crossref 13. Verhaart, W. T. G.: Nederl. tijdschr. v. geneesk. 74:5586, 1930. 14. Jacob, A., cited by von Braunmühl.2 15. Onari, K., and Spatz, N.: Ztschr. f. d. ges. Neurol. u. Psychiat. 101:470, 1926.Crossref 16. Alzheimer, A.: Ztschr. f. d. ges. Neurol. u. Psychiat. 4:356, 1911.Crossref 17. Pick, A.: Monatschr. f. Psychiat. u. Neurol. 16:378, 1904.Crossref 18. Gans, A.: Ztschr f. d. ges. Neurol. u. Psychiat. 80:10, 1922.Crossref 19. Grünthal, E.: Ztschr. f. d. ges. Neurol. u. Psychiat. 136:464, 1931.Crossref 20. von Braunmühl, A.: Zentralbl. f. d. ges. Neurol. u. Psychiat. 48:358, 1931. 21. Korbsch, H.: Arch. f. Psychiat. 100:326, 1933.Crossref 22. Hascovec, V.: Zentralbl. f. d. ges. Neurol. u. Psychiat. 73:345, 1934. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

PICK'S DISEASE: A CLINICOPATHOLOGIC CONTRIBUTION

Archives of Neurology & Psychiatry , Volume 36 (4) – Oct 1, 1936

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Publisher
American Medical Association
Copyright
Copyright © 1936 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1936.02260100095003
Publisher site
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Abstract

Abstract In 1892 Arnold Pick1 published his first observation on atrophy of the brain with focal lesions, which he interpreted as atypical senile dementia. In analyzing the syndrome he was mainly concerned in correlating the clinical picture with the localization of the lesions. The great significance of Pick's contribution was not recognized until later studies proved that the symptom complex originally outlined was in reality a disease entity. The disease is rare, about fifty cases having been reported in the literature. In spite of recent studies clinical diagnosis remains difficult, but knowledge of the pathologic features has been considerably enlarged. Four new cases are reported here. REPORT OF CASES Case 1. —Enda N., aged 47, married, the mother of six children, was admitted to the hospital on May 13, 1931. There were no known hereditary trends. She had had a colloid goiter and "choking spells" for the past several years. References 1. Pick, A.: Beiträge zur Pathologie und pathologischen Anatomie des Centralnervensystems, mit Bemerkungen zur normalen Anatomie desselben , Berlin, S. Karger, 1898. 2. von Braunmühl, A., in von Bumke, O.: Handbuch des Geisteskrankheiten , Berlin, Julius Springer, 1931, vol. II, pt. 7, p. 673. 3. Liepmann: Neurol. Centralbl. 19:328, 1900. 4. Lemke, R.: Arch. f. Psychiat. 101:623, 1934.Crossref 5. van Husen, T.: Allg. Ztschr. f Psychiat. 101: 381, 1934. 6. Schmitz, H. A., and Meyer, A.: Arch f. Psychiat. 99: 747, 1933.Crossref 7. von Braunmühl, A., and Leonhard, K.: Ztschr. f. d. ges. Neurol. u. Psychiat. 150: 209, 1934.Crossref 8. Schneider, C.: Monatschr. f. Psychiat. u. Neurol. 65: 230, 1927.Crossref 9. Stertz, G.: Ztschr. f. d. ges. Neurol. u. Psychiat. 101: 729, 1926.Crossref 10. Rosenfeld, M.: Ztschr. f. Psychol. u. Neurol. 14:115, 1909. 11. Heilbronner: Arch. f Psychiat. 33:366, 1900.Crossref 12. Altmann, E.: Ztschr. f. d. ges. Neurol. u. Psychiat. 83:610, 1923.Crossref 13. Verhaart, W. T. G.: Nederl. tijdschr. v. geneesk. 74:5586, 1930. 14. Jacob, A., cited by von Braunmühl.2 15. Onari, K., and Spatz, N.: Ztschr. f. d. ges. Neurol. u. Psychiat. 101:470, 1926.Crossref 16. Alzheimer, A.: Ztschr. f. d. ges. Neurol. u. Psychiat. 4:356, 1911.Crossref 17. Pick, A.: Monatschr. f. Psychiat. u. Neurol. 16:378, 1904.Crossref 18. Gans, A.: Ztschr f. d. ges. Neurol. u. Psychiat. 80:10, 1922.Crossref 19. Grünthal, E.: Ztschr. f. d. ges. Neurol. u. Psychiat. 136:464, 1931.Crossref 20. von Braunmühl, A.: Zentralbl. f. d. ges. Neurol. u. Psychiat. 48:358, 1931. 21. Korbsch, H.: Arch. f. Psychiat. 100:326, 1933.Crossref 22. Hascovec, V.: Zentralbl. f. d. ges. Neurol. u. Psychiat. 73:345, 1934.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: Oct 1, 1936

References

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