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ORIGINAL INVESTIGATION Physical Activity and Risk of Breast Cancer Among Postmenopausal Women A. Heather Eliassen, ScD; Susan E. Hankinson, RN, ScD; Bernard Rosner, PhD; Michelle D. Holmes, MD, DrPH; Walter C. Willett, MD, DrPH Background: Physical activity has many health ben- 0.93; P.001 for trend). Compared with women who efits. Although greater activity has been related to lower were least active at menopause and through follow-up postmenopausal breast cancer risk, important details re- (9 MET-h/wk [approximately 30 minutes of walking main unclear, including type, intensity, and timing of ac- at an average pace on most days of the week]), women tivity and whether the association varies by subgroups. who increased activity were at lower risk (9 MET- h/wk at menopause and 9 MET-h/wk during follow- Methods: Within the prospective Nurses’ Health Study, up: HR, 0.90; 95% CI, 0.82-0.98). Among specific ac- we assessed the associations of specific and total activ- tivities modeled simultaneously, brisk walking was ity, queried every 2 to 4 years since 1986, with breast can- associated with lower risk (per 20 MET-h/wk [5 h/wk]: cer risk. Cox proportional hazards models were used to HR, 0.91; 95% CI, 0.84-0.98). The association with total calculate hazard ratios (HRs)
JAMA Internal Medicine – American Medical Association
Published: Oct 25, 2010
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