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Phototherapy and Vitamin D

Phototherapy and Vitamin D EDITORIAL N THIS ISSUE OF THE ARCHIVES,RYAN ET AL RE- The study of the role of vitamin D in overall health port the results of a well-designed prospective status has become, in the past few years, a very active area controlled study of patients with psoriasis from of investigation. It is estimated that over 200 genes in the an outpatient dermatology department based in human body are directly or indirectly influenced by 1,25- I Dublin, Ireland. The UV-mediated increase dihydroxyvitamin D [1,25(OH) D]; therefore, it is not in serum 25-hydroxyvitamin D [25(OH)D] was as- surprising that research has focused on the causative links 2,3 sessed in 30 patients with chronic plaque psoriasis at base- and therapeutic implications of this association. On a line, after 4 weeks, and on completion of treatment with molecular level, it has been shown that 1,25(OH) D in- narrowband UV-B (NB–UV-B) therapy during winter- hibits proliferation of malignant cells and promotes dif- time and compared with a control group of patients who ferentiation of normal cells, suggesting a mechanism of 4,5 had not been treated with phototherapy. In the NB– modulating cancer development and progression. The UV-B treatment group, there was a significant increase beneficial http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Dermatology American Medical Association

Phototherapy and Vitamin D

JAMA Dermatology , Volume 146 (8) – Aug 1, 2010

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Publisher
American Medical Association
Copyright
Copyright 2010 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6068
eISSN
2168-6084
DOI
10.1001/archdermatol.2010.193
pmid
20713826
Publisher site
See Article on Publisher Site

Abstract

EDITORIAL N THIS ISSUE OF THE ARCHIVES,RYAN ET AL RE- The study of the role of vitamin D in overall health port the results of a well-designed prospective status has become, in the past few years, a very active area controlled study of patients with psoriasis from of investigation. It is estimated that over 200 genes in the an outpatient dermatology department based in human body are directly or indirectly influenced by 1,25- I Dublin, Ireland. The UV-mediated increase dihydroxyvitamin D [1,25(OH) D]; therefore, it is not in serum 25-hydroxyvitamin D [25(OH)D] was as- surprising that research has focused on the causative links 2,3 sessed in 30 patients with chronic plaque psoriasis at base- and therapeutic implications of this association. On a line, after 4 weeks, and on completion of treatment with molecular level, it has been shown that 1,25(OH) D in- narrowband UV-B (NB–UV-B) therapy during winter- hibits proliferation of malignant cells and promotes dif- time and compared with a control group of patients who ferentiation of normal cells, suggesting a mechanism of 4,5 had not been treated with phototherapy. In the NB– modulating cancer development and progression. The UV-B treatment group, there was a significant increase beneficial

Journal

JAMA DermatologyAmerican Medical Association

Published: Aug 1, 2010

References