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Photosensitivity Reaction to Dibucaine: Case Report and Experimental Induction

Photosensitivity Reaction to Dibucaine: Case Report and Experimental Induction Abstract In a 13-year-old girl, photoallergic dermatitis was caused by dibucaine hydrochloride, which was used as a local anesthetic in the treatment of her dental caries. The action spectrum for the photosensitivity reaction was in the long-wave ultraviolet (UVA) range. Spectrophotometrically, dibucaine absorbed UVA up to 380 nm, and in the vitro irradiated chemical showed an altered absorption spectrum. The agent is fluorescent under UVA light. The allergic photocontact sensitization could be experimentally induced in guinea pigs. The chemical properties and high sensitization rate of experimental induction suggested that dibucaine may be a potent photosensitizing chemical. Dibucaine should be included in routine photopatch test materials. (Arch Dermatol 115:986-987, 1979) References 1. Epstein JH: Photoallergy: A review . Arch Dermatol 106:741-748, 1972.Crossref 2. Smith SZ, Epstein JH: Photocontact dermatitis to halogenated salicylanilides and related compounds . Arch Dermatol 113:1372-1374, 1977.Crossref 3. Mizuno N, Uematsu S, Ohno M, et al: Experimental and clinical studies on photosensitivity due to antibacterial and antifungal agents . J Jpn Med Assoc 74:1165-1186, 1975. 4. Epstein S: Photocontact dermatitis from benzocaine . Arch Dermatol 92:591, 1965.Crossref 5. Horio T: The induction of photocontact sensitivity in guinea pigs without UVB radiation . J Invest Dermatol 67:591-593, 1976.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Photosensitivity Reaction to Dibucaine: Case Report and Experimental Induction

Archives of Dermatology , Volume 115 (8) – Aug 1, 1979

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Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1979.04010080050025
Publisher site
See Article on Publisher Site

Abstract

Abstract In a 13-year-old girl, photoallergic dermatitis was caused by dibucaine hydrochloride, which was used as a local anesthetic in the treatment of her dental caries. The action spectrum for the photosensitivity reaction was in the long-wave ultraviolet (UVA) range. Spectrophotometrically, dibucaine absorbed UVA up to 380 nm, and in the vitro irradiated chemical showed an altered absorption spectrum. The agent is fluorescent under UVA light. The allergic photocontact sensitization could be experimentally induced in guinea pigs. The chemical properties and high sensitization rate of experimental induction suggested that dibucaine may be a potent photosensitizing chemical. Dibucaine should be included in routine photopatch test materials. (Arch Dermatol 115:986-987, 1979) References 1. Epstein JH: Photoallergy: A review . Arch Dermatol 106:741-748, 1972.Crossref 2. Smith SZ, Epstein JH: Photocontact dermatitis to halogenated salicylanilides and related compounds . Arch Dermatol 113:1372-1374, 1977.Crossref 3. Mizuno N, Uematsu S, Ohno M, et al: Experimental and clinical studies on photosensitivity due to antibacterial and antifungal agents . J Jpn Med Assoc 74:1165-1186, 1975. 4. Epstein S: Photocontact dermatitis from benzocaine . Arch Dermatol 92:591, 1965.Crossref 5. Horio T: The induction of photocontact sensitivity in guinea pigs without UVB radiation . J Invest Dermatol 67:591-593, 1976.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1979

References