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Photodynamic Therapy to Treat Tumors of the Extrahepatic Biliary Ducts: A Case Report

Photodynamic Therapy to Treat Tumors of the Extrahepatic Biliary Ducts: A Case Report Abstract • The poor survival rate of patients with extrahepatic bile duct tumors is well documented. Over the course of 4 years, we treated a white woman with diabetes diagnosed with histologically proven adenocarcinoma of the common bile duct with six injections of dihematoporphyrin ether followed by seven photodynamic therapy treatments to the biliary duct. As of July 1989, the patient was still alive, was not jaundiced, and had a Karnofsky performance status of 70. No changes occurred in any blood chemistry value from the time of injection to the time of photodynamic therapy. Of the transient elevations of some blood chemistry values and the white blood cell count, which occurred within 24 to 48 hours after photodynamic therapy, only those of alanine aminotransferase, aspartate aminotransferase, and amylase were significant. (ArchSurg. 1991;126:111-113) References 1. Lai ECS, Tompkins RK, Roslyn JJ, Mann LL. Proximal bile duct cancer: quality of survival . Ann Surg . 1987;205:111-118.Crossref 2. Beazley RM, Hadjis N, Benjamin IS, Blumgart LH. Clinicopathological aspects of high bile duct cancer: experience with resection and bypass surgical treatments . Ann Surg . 1984;199:623-633.Crossref 3. Ouchi K, Matsuno S, Sato T. Long-term survival in carcinoma of the biliary tract . Arch Surg . 1989;124:248-252.Crossref 4. McCaughan JS, Nims TA, Guy JT, Hicks W, Williams TE, Laufman L. Photodynamic therapy for esophageal tumors . Arch Surg . 1989;124:74-80.Crossref 5. McCaughan JS, Guy JT, Hicks W, Laufman L, Nims TA, Walker J. Photodynamic therapy for cutaneous and subcutaneous malignant neoplasms . Arch Surg . 1989;124:211-216.Crossref 6. McCaughan JS, Hawley PC, Walker J. Management of endobronchial tumors: a comparative study . Semin Surg Oncol . 1989;5:38-47.Crossref 7. McCaughan JS, Hawley PC, Bethel BH, Walker J. Photodynamic therapy of endobronchial malignancies . Cancer . 1988;62:691-701.Crossref 8. McCaughan JS. Overview of experiences with photodynamic therapy for malignancy in 192 patients . Photochem Photobiol . 1987;46:903-909.Crossref 9. Weishaupt KR, Gomer CJ. Identification of singlet oxygen as the cytologic agent in photoradiation of a murine tumor . Cancer Res . 1976;36:2326-2329. 10. Dougherty TJ. Photosensitization of malignant tumors . Semin Surg Oncol . 1986;2:24-37.Crossref 11. Passariello R, Pavone R, Rossi P, et al. Percutaneous biliary drainage in neoplastic jaundice . Acta Radiol Diagn . 1985;26:681-688. 12. Molt P, Hopfan S, Watson RC, Botet JF, Brennan MF. Intraluminal radiation therapy in the management of malignant biliary obstruction . Cancer . 1986;57:536-544.Crossref 13. Johnson DW, Safai C, Goffinet DR. Malignant obstruction jaundice: treatment with external beam and intracavitary radiotherapy . Int J Radiat Oncol Biol Phys . 1985;11:411-416.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Photodynamic Therapy to Treat Tumors of the Extrahepatic Biliary Ducts: A Case Report

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Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1991.01410250119022
Publisher site
See Article on Publisher Site

Abstract

Abstract • The poor survival rate of patients with extrahepatic bile duct tumors is well documented. Over the course of 4 years, we treated a white woman with diabetes diagnosed with histologically proven adenocarcinoma of the common bile duct with six injections of dihematoporphyrin ether followed by seven photodynamic therapy treatments to the biliary duct. As of July 1989, the patient was still alive, was not jaundiced, and had a Karnofsky performance status of 70. No changes occurred in any blood chemistry value from the time of injection to the time of photodynamic therapy. Of the transient elevations of some blood chemistry values and the white blood cell count, which occurred within 24 to 48 hours after photodynamic therapy, only those of alanine aminotransferase, aspartate aminotransferase, and amylase were significant. (ArchSurg. 1991;126:111-113) References 1. Lai ECS, Tompkins RK, Roslyn JJ, Mann LL. Proximal bile duct cancer: quality of survival . Ann Surg . 1987;205:111-118.Crossref 2. Beazley RM, Hadjis N, Benjamin IS, Blumgart LH. Clinicopathological aspects of high bile duct cancer: experience with resection and bypass surgical treatments . Ann Surg . 1984;199:623-633.Crossref 3. Ouchi K, Matsuno S, Sato T. Long-term survival in carcinoma of the biliary tract . Arch Surg . 1989;124:248-252.Crossref 4. McCaughan JS, Nims TA, Guy JT, Hicks W, Williams TE, Laufman L. Photodynamic therapy for esophageal tumors . Arch Surg . 1989;124:74-80.Crossref 5. McCaughan JS, Guy JT, Hicks W, Laufman L, Nims TA, Walker J. Photodynamic therapy for cutaneous and subcutaneous malignant neoplasms . Arch Surg . 1989;124:211-216.Crossref 6. McCaughan JS, Hawley PC, Walker J. Management of endobronchial tumors: a comparative study . Semin Surg Oncol . 1989;5:38-47.Crossref 7. McCaughan JS, Hawley PC, Bethel BH, Walker J. Photodynamic therapy of endobronchial malignancies . Cancer . 1988;62:691-701.Crossref 8. McCaughan JS. Overview of experiences with photodynamic therapy for malignancy in 192 patients . Photochem Photobiol . 1987;46:903-909.Crossref 9. Weishaupt KR, Gomer CJ. Identification of singlet oxygen as the cytologic agent in photoradiation of a murine tumor . Cancer Res . 1976;36:2326-2329. 10. Dougherty TJ. Photosensitization of malignant tumors . Semin Surg Oncol . 1986;2:24-37.Crossref 11. Passariello R, Pavone R, Rossi P, et al. Percutaneous biliary drainage in neoplastic jaundice . Acta Radiol Diagn . 1985;26:681-688. 12. Molt P, Hopfan S, Watson RC, Botet JF, Brennan MF. Intraluminal radiation therapy in the management of malignant biliary obstruction . Cancer . 1986;57:536-544.Crossref 13. Johnson DW, Safai C, Goffinet DR. Malignant obstruction jaundice: treatment with external beam and intracavitary radiotherapy . Int J Radiat Oncol Biol Phys . 1985;11:411-416.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Jan 1, 1991

References