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Photodynamic Inactivation of Herpes Simplex

Photodynamic Inactivation of Herpes Simplex Herpes simplex virus can be inactivated if exposed to any of several heterotricyclic dyes and irradiated briefly with an ordinary fluorescent light. This finding has been applied in a double-blind study in a group of patients with at least four episodes of recurrent herpes simplex infection per year. Therapy consisted of rupturing early vesicular lesions, application of the dye, and subsequent exposure to fluorescent light for 15 minutes. Eighteen of 20 patients treated with the active medication noted symptomatic improvement superior to that experienced with any form of therapy previously used. Also, in virtually all patients a 50% or greater improvement in healing time was noted. After follow-up study from 18 to 30 months, 85% of the patients had a 50% or greater decrease in recurrence rate and only 11% had a recurrence to exactly the same site. These results were superior to those obtained in a group of 12 control patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Photodynamic Inactivation of Herpes Simplex

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Publisher
American Medical Association
Copyright
Copyright © 1973 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1973.03220030027005
Publisher site
See Article on Publisher Site

Abstract

Herpes simplex virus can be inactivated if exposed to any of several heterotricyclic dyes and irradiated briefly with an ordinary fluorescent light. This finding has been applied in a double-blind study in a group of patients with at least four episodes of recurrent herpes simplex infection per year. Therapy consisted of rupturing early vesicular lesions, application of the dye, and subsequent exposure to fluorescent light for 15 minutes. Eighteen of 20 patients treated with the active medication noted symptomatic improvement superior to that experienced with any form of therapy previously used. Also, in virtually all patients a 50% or greater improvement in healing time was noted. After follow-up study from 18 to 30 months, 85% of the patients had a 50% or greater decrease in recurrence rate and only 11% had a recurrence to exactly the same site. These results were superior to those obtained in a group of 12 control patients.

Journal

JAMAAmerican Medical Association

Published: Jan 15, 1973

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