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Photochemotherapy of Vitiligo: Use of Orally Administered Psoralens and a High-Intensity Long-Wave Ultraviolet Light System

Photochemotherapy of Vitiligo: Use of Orally Administered Psoralens and a High-Intensity... Abstract • A new light source that provides highintensity ultraviolet light (UVA) (300 to 400 nm) to the entire body surface makes orally administered psoralen treatment of vitiligo with an artificial light practical. In the 26 patients studied, the degree of repigmentation with either trioxsalen (TMP) or methoxsalen (8-MOP) and high intensity UVA was at least as great as that with the same oral agents and sunlight. With artificial UVA and similar treatment conditions, the two psoralen derivatives were compared in the treatment of vitiligo; TMP stimulated repigmentation as well as 8-MOP and caused fewer side effects. (Arch Dermatol 112:1531-1534, 1976) References 1. Fitzpatrick TB, Parrish JA, Pathak MA: Phatotherapy of vitiligo (idiopathic leukoderma) , in Pathak MA, Harber LC, Seiji M, et al (eds): Sunlight and Man, Normal and Abnormal Photobiologic Responses . Tokyo, University of Tokyo Press, 1974, pp 783-791. 2. Cunliffe WJ, Hall R, Newell DJ, et al: Vitiligo, thyroid disease and autoimmunity . Br J Dermatol 80:135-139, 1968.Crossref 3. Lerner AB: On the etiology of vitiligo and gray hair . Am J Med 51:141-147, 1971.Crossref 4. Fitzpatrick TB, Mihm MC Jr: Abnormalities of the melanin pigmentary system , in Fitzpatrick TB, Arndt KA, Clark WH Jr, et al (eds): Dermatology in General Medicine . New York, McGraw-Hill Book Co.Inc, 1971, pp 1591-1637. 5. Lerner AB: Vitiligo . Prog Dermatol 6:1-6, 1972. 6. Kandil E: Vitiligo—response to 0.2% betamethasome 17-valerate in flexible collodion . Dermatologica 141:277-281, 1970.Crossref 7. Kandil E: Treatment of localized vitiligo with intradermal injections of triamcinolone acetonide . Dermatologica 140:195-206, 1970.Crossref 8. Verbov J: Use of Ciba 1906 (thimbutosine BP) in vitiligo . Br J Dermatol 87:81-82, 1972.Crossref 9. Woolfson H, Finn OA: Topical levodopa in vitiligo . Lancet 1:598, 1972.Crossref 10. Bor S: Clofazimine (lamprene) in the treatment of vitiligo . S Afr Med J 47:1451-1454, 1973. 11. Fulton JE, Leyden J, Papa C: Treatment of vitiligo with topical methoxsalen and blacklite . Arch Dermatol 100:224-229, 1969.Crossref 12. Africk J, Fulton J: Treatment of vitiligo with topical trimethylpsoralen and sunlight . Br J Dermatol 84:151-156, 1971.Crossref 13. Kelly EW Jr, Pinkus H: Local application of 8-methoxypsoralen in vitiligo . J Invest Dermatol 25:453-456, 1955.Crossref 14. El Mofty AM: A preliminary clinical report on the treatment of leukoderma with ammimajus linn . J Egypt Med Assoc 31:651-665, 1948. 15. Fitzpatrick TB, Arndt KA, El Mofty AM, et al: Hydroquinone and psoralens in the therapy of hypermelanosis and vitiligo . Arch Dermatol 93:589-600, 1966.Crossref 16. Becker SW Jr: Psoralen phototherapeutic agents . JAMA 202:422-424, 1967.Crossref 17. Lerner AB, Denton CR, Fitzpatrick TB: Clinical and experimental studies with 8-methoxypsoralen in vitiligo . J Invest Dermatol 20:299-314, 1953. 18. Elliott JA: Methoxsalen in the treatment of vitiligo . Arch Dermatol 79:237-243, 1959.Crossref 19. Kenney JA Jr: Vitiligo treated by psoralens . Arch Dermatol 103:475-480, 1971.Crossref 20. Bleehen SS: Treatment of vitiligo with oral 4,5'8-trimethylpsoralen (Trisoralen) . Br J Dermatol 86:54-60, 1972.Crossref 21. Kobori T, Toda K: Treatment of vitiligo with trimethylpsoralen . Jap J Clin Dermatol 27:983, 1973. 22. Levin RE, Parrish JA: Phototherapy of vitiligo . Lighting Design Appl , (March) 1975, pp 35-43. 23. Parrish JA, Fitzpatrick TB, Tanenbaum L, et al: Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light . N Engl J Med 291:1207-1211, 1974.Crossref 24. Kligman AM, Goldstein FP: Ineffectiveness of trioxsalen as an oral photosensitizer . Arch Dermatol 107:413-414, 1973.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Photochemotherapy of Vitiligo: Use of Orally Administered Psoralens and a High-Intensity Long-Wave Ultraviolet Light System

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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1976.01630350007002
Publisher site
See Article on Publisher Site

Abstract

Abstract • A new light source that provides highintensity ultraviolet light (UVA) (300 to 400 nm) to the entire body surface makes orally administered psoralen treatment of vitiligo with an artificial light practical. In the 26 patients studied, the degree of repigmentation with either trioxsalen (TMP) or methoxsalen (8-MOP) and high intensity UVA was at least as great as that with the same oral agents and sunlight. With artificial UVA and similar treatment conditions, the two psoralen derivatives were compared in the treatment of vitiligo; TMP stimulated repigmentation as well as 8-MOP and caused fewer side effects. (Arch Dermatol 112:1531-1534, 1976) References 1. Fitzpatrick TB, Parrish JA, Pathak MA: Phatotherapy of vitiligo (idiopathic leukoderma) , in Pathak MA, Harber LC, Seiji M, et al (eds): Sunlight and Man, Normal and Abnormal Photobiologic Responses . Tokyo, University of Tokyo Press, 1974, pp 783-791. 2. Cunliffe WJ, Hall R, Newell DJ, et al: Vitiligo, thyroid disease and autoimmunity . Br J Dermatol 80:135-139, 1968.Crossref 3. Lerner AB: On the etiology of vitiligo and gray hair . Am J Med 51:141-147, 1971.Crossref 4. Fitzpatrick TB, Mihm MC Jr: Abnormalities of the melanin pigmentary system , in Fitzpatrick TB, Arndt KA, Clark WH Jr, et al (eds): Dermatology in General Medicine . New York, McGraw-Hill Book Co.Inc, 1971, pp 1591-1637. 5. Lerner AB: Vitiligo . Prog Dermatol 6:1-6, 1972. 6. Kandil E: Vitiligo—response to 0.2% betamethasome 17-valerate in flexible collodion . Dermatologica 141:277-281, 1970.Crossref 7. Kandil E: Treatment of localized vitiligo with intradermal injections of triamcinolone acetonide . Dermatologica 140:195-206, 1970.Crossref 8. Verbov J: Use of Ciba 1906 (thimbutosine BP) in vitiligo . Br J Dermatol 87:81-82, 1972.Crossref 9. Woolfson H, Finn OA: Topical levodopa in vitiligo . Lancet 1:598, 1972.Crossref 10. Bor S: Clofazimine (lamprene) in the treatment of vitiligo . S Afr Med J 47:1451-1454, 1973. 11. Fulton JE, Leyden J, Papa C: Treatment of vitiligo with topical methoxsalen and blacklite . Arch Dermatol 100:224-229, 1969.Crossref 12. Africk J, Fulton J: Treatment of vitiligo with topical trimethylpsoralen and sunlight . Br J Dermatol 84:151-156, 1971.Crossref 13. Kelly EW Jr, Pinkus H: Local application of 8-methoxypsoralen in vitiligo . J Invest Dermatol 25:453-456, 1955.Crossref 14. El Mofty AM: A preliminary clinical report on the treatment of leukoderma with ammimajus linn . J Egypt Med Assoc 31:651-665, 1948. 15. Fitzpatrick TB, Arndt KA, El Mofty AM, et al: Hydroquinone and psoralens in the therapy of hypermelanosis and vitiligo . Arch Dermatol 93:589-600, 1966.Crossref 16. Becker SW Jr: Psoralen phototherapeutic agents . JAMA 202:422-424, 1967.Crossref 17. Lerner AB, Denton CR, Fitzpatrick TB: Clinical and experimental studies with 8-methoxypsoralen in vitiligo . J Invest Dermatol 20:299-314, 1953. 18. Elliott JA: Methoxsalen in the treatment of vitiligo . Arch Dermatol 79:237-243, 1959.Crossref 19. Kenney JA Jr: Vitiligo treated by psoralens . Arch Dermatol 103:475-480, 1971.Crossref 20. Bleehen SS: Treatment of vitiligo with oral 4,5'8-trimethylpsoralen (Trisoralen) . Br J Dermatol 86:54-60, 1972.Crossref 21. Kobori T, Toda K: Treatment of vitiligo with trimethylpsoralen . Jap J Clin Dermatol 27:983, 1973. 22. Levin RE, Parrish JA: Phototherapy of vitiligo . Lighting Design Appl , (March) 1975, pp 35-43. 23. Parrish JA, Fitzpatrick TB, Tanenbaum L, et al: Photochemotherapy of psoriasis with oral methoxsalen and longwave ultraviolet light . N Engl J Med 291:1207-1211, 1974.Crossref 24. Kligman AM, Goldstein FP: Ineffectiveness of trioxsalen as an oral photosensitizer . Arch Dermatol 107:413-414, 1973.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Nov 1, 1976

References