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Photo-Irradiation Studies of Two Tetracyclines: Tetracycline and Demethylchlortetracycline

Photo-Irradiation Studies of Two Tetracyclines: Tetracycline and Demethylchlortetracycline Abstract Both tetracycline (TET) and demethylchlortetracycline (DMC) are photosensitive substances under the conditions of this experiment. Ultraviolet wavelengths which pass through common window glass (>315 mμ) will activate this response in human skin. DMC appears to have greater photoresponse potential per unit concentration than tetracycline. A hot quartz lamp appears to be an inadequate light source for these studies, when compared with natural sunlight. References 1. It should be noted that the neutral salts are less soluble than the hydrochloride and were, therefore, not used in this study. 2. Obtained through the courtesy of Lederle Laboratories. 3. Falk, M. S.: Light Sensitivity Due to Demethylchlortetracycline , JAMA 172:1156, 1960.Crossref 4. Trafton, H. M., and Find, H. E.: Demethylchlortetracycline: Effectiveness and Tolerance in Urinary Tract Infections , Antibiot Med 7:449, 1960. 5. Morris, W. E.: Photosensitivity Due to Tetracycline Derivative , JAMA 172:1155, 1960.Crossref 6. Fuhrman, D. L., and Drowns, B. V.: Demethylchlortetracycline: The Clinical Aspect of Its Use in Dermatology , Arch Derm 82:244, 1960.Crossref 7. Orentreich, N.; Harber, L. C.; and Tromovitch, T. A.: Photosensitivity and Photo-Onycholysis Due to Demethylchlortetracycline , Arch Derm 83:730, 1961.Crossref 8. Wolf, M. L.: Case Report: Photosensitivity to Demethylchlortetracycline , J Tenn Med Ass 54: 121, 1961. 9. Zöllner, N., and Parrisius, G.: Photodynamische Reaktionen nach Verabreichung von Demethylchlortetracycline , Med Welt 33-34:1682, 1960. 10. Deveber, L. L.: Photosensitivity, Loosening of the Nails and Discoloration of the Nails and Teeth in Association with Demethylchlortetracycline: Report of a Case With Review of Other Reported Cases , Canad Med Ass J 86:168, 1962. 11. Saslaw, S.: Demethylchlortetracycline Phototoxicity , New Eng J Med 264:1301, 1961.Crossref 12. Cahn, M. M.; Levy, E. J.; and McMillen, J. A.: Nature and Incidence of Photosensitivity Reactions to Demethylchlortetracycline , Arch Derm 84:485, 1961.Crossref 13. Epstein, S.: Photoallergy and Primary Photosensitivity to Sulfanilamide , J Invest Derm 2:43, 1939.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Photo-Irradiation Studies of Two Tetracyclines: Tetracycline and Demethylchlortetracycline

Archives of Dermatology , Volume 88 (4) – Oct 1, 1963

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Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1963.01590220072008
Publisher site
See Article on Publisher Site

Abstract

Abstract Both tetracycline (TET) and demethylchlortetracycline (DMC) are photosensitive substances under the conditions of this experiment. Ultraviolet wavelengths which pass through common window glass (>315 mμ) will activate this response in human skin. DMC appears to have greater photoresponse potential per unit concentration than tetracycline. A hot quartz lamp appears to be an inadequate light source for these studies, when compared with natural sunlight. References 1. It should be noted that the neutral salts are less soluble than the hydrochloride and were, therefore, not used in this study. 2. Obtained through the courtesy of Lederle Laboratories. 3. Falk, M. S.: Light Sensitivity Due to Demethylchlortetracycline , JAMA 172:1156, 1960.Crossref 4. Trafton, H. M., and Find, H. E.: Demethylchlortetracycline: Effectiveness and Tolerance in Urinary Tract Infections , Antibiot Med 7:449, 1960. 5. Morris, W. E.: Photosensitivity Due to Tetracycline Derivative , JAMA 172:1155, 1960.Crossref 6. Fuhrman, D. L., and Drowns, B. V.: Demethylchlortetracycline: The Clinical Aspect of Its Use in Dermatology , Arch Derm 82:244, 1960.Crossref 7. Orentreich, N.; Harber, L. C.; and Tromovitch, T. A.: Photosensitivity and Photo-Onycholysis Due to Demethylchlortetracycline , Arch Derm 83:730, 1961.Crossref 8. Wolf, M. L.: Case Report: Photosensitivity to Demethylchlortetracycline , J Tenn Med Ass 54: 121, 1961. 9. Zöllner, N., and Parrisius, G.: Photodynamische Reaktionen nach Verabreichung von Demethylchlortetracycline , Med Welt 33-34:1682, 1960. 10. Deveber, L. L.: Photosensitivity, Loosening of the Nails and Discoloration of the Nails and Teeth in Association with Demethylchlortetracycline: Report of a Case With Review of Other Reported Cases , Canad Med Ass J 86:168, 1962. 11. Saslaw, S.: Demethylchlortetracycline Phototoxicity , New Eng J Med 264:1301, 1961.Crossref 12. Cahn, M. M.; Levy, E. J.; and McMillen, J. A.: Nature and Incidence of Photosensitivity Reactions to Demethylchlortetracycline , Arch Derm 84:485, 1961.Crossref 13. Epstein, S.: Photoallergy and Primary Photosensitivity to Sulfanilamide , J Invest Derm 2:43, 1939.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Oct 1, 1963

References