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Phenytoin and Cerebellar Atrophy

Phenytoin and Cerebellar Atrophy Abstract I read with interest the valuable study by Ney et al1 on cerebellar atrophy in patients with complex partial seizures who were taking phenytoin. Sixteen of their 36 patients had no history of generalized tonicclonic seizures. Among these 16 patients, was there a higher incidence of atrophy than that expected in the control population? In a study using positron emission tomography with 18F-deoxyglucose, we found that cerebellar glucose metabolism was reduced in patients with complex partial seizures compared with control subjects.2 In our study, the effects of phenytoin were weak. I agree with Ney et al that phenytoin may have some influence on the development of cerebellar atrophy in patients with epilepsy, but I do not think that the effect is likely to be of clinical importance. Lindvall et al3 described a patient with acute subarachnoid hemorrhage who never had seizures, but who developed ataxia and References 1. Ney GC, Lantos G, Barr WB, Schaul N. Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy . Arch Neurol . 1994;51:767-771.Crossref 2. Theodore WH, Fishbein D, Deitz M, Baldwin P. Complex partial seizures: cerebellar metabolism . Epilepsia . 1987;28:319-323.Crossref 3. Lindvall O, Nilsson B. Cerebellar atrophy following phenytoin intoxication . Ann Neurol . 1984;16:258-260.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Phenytoin and Cerebellar Atrophy

Archives of Neurology , Volume 52 (3) – Mar 1, 1995

Phenytoin and Cerebellar Atrophy

Abstract

Abstract I read with interest the valuable study by Ney et al1 on cerebellar atrophy in patients with complex partial seizures who were taking phenytoin. Sixteen of their 36 patients had no history of generalized tonicclonic seizures. Among these 16 patients, was there a higher incidence of atrophy than that expected in the control population? In a study using positron emission tomography with 18F-deoxyglucose, we found that cerebellar glucose metabolism was reduced in patients with complex...
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Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1995.00540270018008
Publisher site
See Article on Publisher Site

Abstract

Abstract I read with interest the valuable study by Ney et al1 on cerebellar atrophy in patients with complex partial seizures who were taking phenytoin. Sixteen of their 36 patients had no history of generalized tonicclonic seizures. Among these 16 patients, was there a higher incidence of atrophy than that expected in the control population? In a study using positron emission tomography with 18F-deoxyglucose, we found that cerebellar glucose metabolism was reduced in patients with complex partial seizures compared with control subjects.2 In our study, the effects of phenytoin were weak. I agree with Ney et al that phenytoin may have some influence on the development of cerebellar atrophy in patients with epilepsy, but I do not think that the effect is likely to be of clinical importance. Lindvall et al3 described a patient with acute subarachnoid hemorrhage who never had seizures, but who developed ataxia and References 1. Ney GC, Lantos G, Barr WB, Schaul N. Cerebellar atrophy in patients with long-term phenytoin exposure and epilepsy . Arch Neurol . 1994;51:767-771.Crossref 2. Theodore WH, Fishbein D, Deitz M, Baldwin P. Complex partial seizures: cerebellar metabolism . Epilepsia . 1987;28:319-323.Crossref 3. Lindvall O, Nilsson B. Cerebellar atrophy following phenytoin intoxication . Ann Neurol . 1984;16:258-260.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Mar 1, 1995

References