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PHENOLPHTHALEIN STUDIES

PHENOLPHTHALEIN STUDIES The discoverer of the cathartic action of phenolphthalein, Zoltan von Vamossy,1 determined that more than 85 per cent of ingested phenolphthalein is eliminated in the dog's feces and that merely a minimal quantity of free phenolphthalein is occasionally to be found in the urine on the addition of alkali. He also noted in dogs, after the giving of enormous doses, an increase in the conjugated sulfates in the urine.2 Kastle probably was the first to discover the presence of conjugated phenolphthalein in the urine. After giving a dose of 0.5 Gm. of phenolphthalein intraperitoneally to a guinea pig he observed the excretion of conjugated phenolphthalein in the urine for twenty days. Fleig3 studied exhaustively the fate of phenolphthalein in the system, and he as well as others concluded that phenolphthalein is so stable a compound that it is not decomposed into phenol and phthalic acid in the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

PHENOLPHTHALEIN STUDIES

JAMA , Volume 110 (11) – Mar 12, 1938

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Publisher
American Medical Association
Copyright
Copyright © 1938 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1938.02790110022007
Publisher site
See Article on Publisher Site

Abstract

The discoverer of the cathartic action of phenolphthalein, Zoltan von Vamossy,1 determined that more than 85 per cent of ingested phenolphthalein is eliminated in the dog's feces and that merely a minimal quantity of free phenolphthalein is occasionally to be found in the urine on the addition of alkali. He also noted in dogs, after the giving of enormous doses, an increase in the conjugated sulfates in the urine.2 Kastle probably was the first to discover the presence of conjugated phenolphthalein in the urine. After giving a dose of 0.5 Gm. of phenolphthalein intraperitoneally to a guinea pig he observed the excretion of conjugated phenolphthalein in the urine for twenty days. Fleig3 studied exhaustively the fate of phenolphthalein in the system, and he as well as others concluded that phenolphthalein is so stable a compound that it is not decomposed into phenol and phthalic acid in the

Journal

JAMAAmerican Medical Association

Published: Mar 12, 1938

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